An efficient synthesis of anti-microbial 1,2,4-triazole-3-thiones promoted by acidic ionic liquid

An efficient synthesis of anti-microbial 1,2,4-triazole-3-thiones promoted by acidic ionic liquid Acidic ionic liquid, [(Py)2SO][HSO4]2 has been used as an efficient catalyst for the reaction of ketone with thiosemicarbazide in ethanol at room temperature for the eco-friendly synthesis of spiro-1,2,4-triazolidine-3-thiones. Smooth reactions, ambient temperature, use of alcohol as a solvent, high yields, easy work-up procedure and excellent recyclability of ionic liquid and high atom economy are the auxiliary advantages of the present protocol, which makes it ecofriendly. All the synthesized 1,2,4-trioazoles were screened for antimicrobial activity. Most of compounds displayed moderate to good biological activity. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

An efficient synthesis of anti-microbial 1,2,4-triazole-3-thiones promoted by acidic ionic liquid

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Publisher
Springer Netherlands
Copyright
Copyright © 2015 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-015-2267-z
Publisher site
See Article on Publisher Site

Abstract

Acidic ionic liquid, [(Py)2SO][HSO4]2 has been used as an efficient catalyst for the reaction of ketone with thiosemicarbazide in ethanol at room temperature for the eco-friendly synthesis of spiro-1,2,4-triazolidine-3-thiones. Smooth reactions, ambient temperature, use of alcohol as a solvent, high yields, easy work-up procedure and excellent recyclability of ionic liquid and high atom economy are the auxiliary advantages of the present protocol, which makes it ecofriendly. All the synthesized 1,2,4-trioazoles were screened for antimicrobial activity. Most of compounds displayed moderate to good biological activity.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Oct 12, 2015

References

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