An efficient and facile synthesis of 2-amino-4-aryl-3,5-dicarbonitrile-6-ethoxypyridine via reaction of aromatic aldehydes, malononitrile, and ethanol in the presence of NaOH has been developed, without using the classic reagents amines and 1,3-dicarbonyl compounds. It is interesting that weak nucleophilic reagent ethanol could take part in the reaction without using strong base catalyst sodium ethylate. Compared with existing methods, the reported process has the advantages of excellent yields, easily obtainable raw materials, and mild reaction conditions.
Research on Chemical Intermediates – Springer Journals
Published: Oct 2, 2012
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