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- Publisher
- Springer Journals
- Copyright
- Copyright © 2014 by Springer Science+Business Media Dordrecht
- Subject
- Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
- ISSN
- 0922-6168
- eISSN
- 1568-5675
- DOI
- 10.1007/s11164-014-1719-1
- Publisher site
- See Article on Publisher Site
Abstract
A synthetic method for 2-formylcyclopent-2-enecarboxylic acid is described. This procedure comprises two steps. The first step is a [2 + 2] cycloaddition reaction, and the second step is a hydrolysis and ring-opening reaction. A plausible mechanism of the hydrolysis and ring-opening reaction was supposed. Then, the effects of different solvents, base mol ratio, concentration of base, and reaction temperature on the yield of the second step were studied. Finally, under the obtained optimized conditions, the product was achieved and isolated in 59.4 % yield, which was more than double the ones reported previously. An improved and efficient procedure for the synthesis of 2-formylcyclopent-2-enecarboxylic acid has been developed.
Journal
Research on Chemical Intermediates – Springer Journals
Published: Jun 24, 2014