An efficient and eco-friendly procedure for the one-pot synthesis of biologically active heterocyclic compounds including indazolo[1,2-b]-phthalazinetriones has been developed in the presence of Fe3O4@SiO2 nanoparticles. The multicomponent reactions of aldehydes, dimedone, and phthalhydrazide were carried out under solvent-free conditions to obtain some indazolo[1,2-b]-phthalazinetrione derivatives. The present approach provides several advantages such as excellent yields, a simple workup, low reaction times, easy catalyst separation, and little catalyst loading.
Research on Chemical Intermediates – Springer Journals
Published: Dec 14, 2014
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