J Mater Sci: Mater Med (2018) 29:2 DOI 10.1007/s10856-017-6007-3 DELIVERY SYSTEMS Original Research An effective delivery vehicle of demineralized bone matrix incorporated with engineered collagen-binding human bone morphogenetic protein-2 to accelerate spinal fusion at low dose 1 1 1 1 1 1 ● ● ● ● ● ● Weiguo Zhu Yong Qiu Fei Sheng Xinxin Yuan Leilei Xu Hongda Bao 2 1 Jianwu Dai Zezhang Zhu Received: 10 August 2017 / Accepted: 17 November 2017 / Published online: 1 December 2017 © Springer Science+Business Media, LLC, part of Springer Nature 2017 Abstract The aim of this study was to investigate the binding BMP-2 was a feasible and promising bone repair feasibility and efﬁcacy of a new delivery matrix using vehicle. demineralized bone matrix (DBM) incorporated with collagen-binding bone morphogenetic protein-2 (CBD- Graphical abstract The present study showed better BMP-2) in the rat inter-transverse spinal fusion model. results in terms of plain radiography, CT + 3D reconstruc- Sixty rats undergoing posterolateral (inter-transverse) spinal tion, manual palpation and histological evaluation in the rat fusion were divided into 3 groups according to the fusion inter-transverse spinal fusion model using DBM+CBD- materials containing different components (n = 20 per BMP-2, compared with DBM+BMP-2
Journal of Materials Science: Materials in Medicine – Springer Journals
Published: Dec 1, 2017
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