Keywords Magnetic cellulose Nanocatalyst Sulfonic acid Green solvent Introduction Multi-component reactions are known as versatile synthesis tools for the assembly of novel and structurally complex molecules from simple starting materials in a minimum of reaction steps . These reactions have emerged as a valuable method for the formation and breakage of carbon–carbon and carbon-heteroatom bonds in a one-pot and simple work-up procedure. The synthesis of highly functionalized quinolines illustrates the proper application of multi-component reactions because the quinoline moiety possesses promising biological activities, such as antimalarial, anticancer, antimicrobial , antiallergy, and anti-inﬂammatory activities, which essentially associate to the nature and the place of the substituents . In addition to the abovementioned activities, pyridopyrimidins show a broad spectrum of biological and pharmacological activity, including antiﬂoate, tyrosine kinase inhibitors, anti- aggressive , antitumor, cardiotonic, heptoprotactive, antifungal, antibronchitic , and calcium antagonist . Recently, effort has been made in order to replace the traditional liquid inorganic homogeneous acid, with heterogeneous ones, because of their environmental, economical and industrial aspects. To address the aforementioned issues, the covalently immobilized –SO H group onto the surface of a solid support is one of the most common methods to develop the novel heterogeneous
Research on Chemical Intermediates – Springer Journals
Published: Oct 11, 2016
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