In this work, an efﬁcient and green protocol for the synthesis of newly prepared acyl-substituted bis(pyrazolyl)methane derivatives has been introduced via a one-pot, three-component (2 ? 1) condensation reaction by the use of 3-methyl-1- phenyl-2-pyrazolin-5-one, arylglyoxal derivatives, and silica sodium carbonate (SSC) as a recyclable green catalyst. All synthesized products were obtained with good to excellent yields, and their structures were deduced by FT-IR, HNMR, C NMR spectroscopies, and (C, H, N, S) elemental analyses. The capability of SSC to be reused can be considered as one of this procedure’s advantages. The studies on the reusability of catalyst revealed that SSC can efﬁciently catalyze this condensation reaction up to six times without signiﬁcant loss of activity. Graphical abstract Keywords Arylglyoxals Acyl-substituted bis(pyrazolyl)methanes Green technology Recyclable catalyst Aqueous media Silica sodium carbonate Introduction Among chemicals, organic compounds are well-known, outstanding materials. Many important chemicals in the & Khalil Eskandari firstname.lastname@example.org world such as vitamins, natural products, biomolecules, and a wide range of biologically active substances belong Department of Medicinal Chemistry, Faculty of Pharmacy to organic compounds. Most of them have been exhibited and Pharmaceutics Research Center, Institute of in biological activities and have considered them as
Monatshefte für Chemie - Chemical Monthly – Springer Journals
Published: Dec 7, 2017
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