An eco-compatible, three-component synthesis of acyl-substituted bis(pyrazolyl)methanes by employing recyclable silica sodium carbonate as an efficient and environmentally benign catalyst in aqueous medium

An eco-compatible, three-component synthesis of acyl-substituted bis(pyrazolyl)methanes by... In this work, an efficient and green protocol for the synthesis of newly prepared acyl-substituted bis(pyrazolyl)methane derivatives has been introduced via a one-pot, three-component (2 ? 1) condensation reaction by the use of 3-methyl-1- phenyl-2-pyrazolin-5-one, arylglyoxal derivatives, and silica sodium carbonate (SSC) as a recyclable green catalyst. All synthesized products were obtained with good to excellent yields, and their structures were deduced by FT-IR, HNMR, C NMR spectroscopies, and (C, H, N, S) elemental analyses. The capability of SSC to be reused can be considered as one of this procedure’s advantages. The studies on the reusability of catalyst revealed that SSC can efficiently catalyze this condensation reaction up to six times without significant loss of activity. Graphical abstract Keywords Arylglyoxals  Acyl-substituted bis(pyrazolyl)methanes  Green technology  Recyclable catalyst Aqueous media  Silica sodium carbonate Introduction Among chemicals, organic compounds are well-known, outstanding materials. Many important chemicals in the & Khalil Eskandari khalileskandari@yahoo.com world such as vitamins, natural products, biomolecules, and a wide range of biologically active substances belong Department of Medicinal Chemistry, Faculty of Pharmacy to organic compounds. Most of them have been exhibited and Pharmaceutics Research Center, Institute of in biological activities and have considered them as http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Monatshefte für Chemie - Chemical Monthly Springer Journals

An eco-compatible, three-component synthesis of acyl-substituted bis(pyrazolyl)methanes by employing recyclable silica sodium carbonate as an efficient and environmentally benign catalyst in aqueous medium

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Publisher
Springer Vienna
Copyright
Copyright © 2017 by Springer-Verlag GmbH Austria, part of Springer Nature
Subject
Chemistry; Chemistry/Food Science, general; Organic Chemistry; Inorganic Chemistry; Analytical Chemistry; Physical Chemistry; Theoretical and Computational Chemistry
ISSN
0026-9247
eISSN
1434-4475
D.O.I.
10.1007/s00706-017-2106-6
Publisher site
See Article on Publisher Site

Abstract

In this work, an efficient and green protocol for the synthesis of newly prepared acyl-substituted bis(pyrazolyl)methane derivatives has been introduced via a one-pot, three-component (2 ? 1) condensation reaction by the use of 3-methyl-1- phenyl-2-pyrazolin-5-one, arylglyoxal derivatives, and silica sodium carbonate (SSC) as a recyclable green catalyst. All synthesized products were obtained with good to excellent yields, and their structures were deduced by FT-IR, HNMR, C NMR spectroscopies, and (C, H, N, S) elemental analyses. The capability of SSC to be reused can be considered as one of this procedure’s advantages. The studies on the reusability of catalyst revealed that SSC can efficiently catalyze this condensation reaction up to six times without significant loss of activity. Graphical abstract Keywords Arylglyoxals  Acyl-substituted bis(pyrazolyl)methanes  Green technology  Recyclable catalyst Aqueous media  Silica sodium carbonate Introduction Among chemicals, organic compounds are well-known, outstanding materials. Many important chemicals in the & Khalil Eskandari khalileskandari@yahoo.com world such as vitamins, natural products, biomolecules, and a wide range of biologically active substances belong Department of Medicinal Chemistry, Faculty of Pharmacy to organic compounds. Most of them have been exhibited and Pharmaceutics Research Center, Institute of in biological activities and have considered them as

Journal

Monatshefte für Chemie - Chemical MonthlySpringer Journals

Published: Dec 7, 2017

References

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