NH O H O 3 H O 2 2 Cl Cl H O O 1 O H C N 3 H C NH 2 H O OH H O 2 H O 4a-i 80°C, Stiring OH R= CH ,OCH ,Cl, Br,NO ,F, CF 3 3 2 3 HS R =H,CH 1 3 Electronic supplementary material The online version of this article (doi:10.1007/s11164-016-2604-x) contains supplementary material, which is available to authorized users. & Ruby Singh email@example.com Department of Chemistry, School of Basic Sciences, Jaipur National University, Jaipur, Rajasthan, India 123 46 R. Singh, S. A. Ganaie Keywords Multi-component reaction Acenaphthylene-1,2-dione Mercaptocarboxylic acid Spiro[acenaphthylene-thiazolidinones] Thiamine hydrochloride Introduction The discovery of new synthetic methodologies that facilitate the preparation of organic compounds is a central point of research activity in the ﬁeld of modern organic, bio-organic, and medicinal chemistry [1, 2]. One approach to address this challenge involves the development of multicomponent reactions (MCRs), in which three or more reactants are combined together in a single reaction vessel to produce a product incorporating most of the atoms contained in the starting materials [3, 4]. Thia-azaheterocycles have attracted considerable attention because of their wide biological and pharmacological activities [5–7]. 4-Thiazolidinones are
Research on Chemical Intermediates – Springer Journals
Published: Jun 13, 2016
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