Mammalian Genome 12, 86–88 (2001). DOI: 10.1007/s003350010237 Incorporating Mouse Genome © Springer-Verlag New York Inc. 2001 An ATP-binding cassette gene (ABCG3) closely related to the multidrug transporter ABCG2 (MXR/ABCP) has an unusual ATP-binding domain 1 2 1 2, 1 1 1 Lyn Mickley, Pawan Jain, Keisuke Miyake, Lynn M. Schriml, * Konetti Rao, Tito Fojo, Susan Bates, Michael Dean Medicine Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA Laboratory of Genomic Diversity, NCI-FCRDC, Bldg 560, Rm 21-18, Frederick, MD 21702, USA Received 26 May 2000 / Accepted 11 September 2000 The recent identification of multiple ABC transporters with poten- throughout the coding region. Abcg3 is most closely related to tial roles in drug resistance has offered hope for the treatment of ABCG2 with 54% amino acid identity overall, 64% in the NBF cancer (Borst 1999; Sandor et al. 1998). ATP binding cassette and 50% in the TM region. The alignment was used to generate a (ABC) proteins bind and hydrolyze ATP providing energy for the phylogenetic tree of the genes, and this analysis confirms that transport of an array of substrates (Dean and Allikmets 1995; Abcg3 and ABCG2 are closely related (data not shown). Surpris- Higgins 1992). MDR1/P-glycoprotein
Mammalian Genome – Springer Journals
Published: Jan 1, 2001
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