Aminolevulinic acid

Aminolevulinic acid Reactions 1680, p26 - 2 Dec 2017 Pain, erythema and post-inflammatory hyperpigmentation: 2 case reports In a case series, two patients (a 17-years-old boy and a 25-year-old woman) were described, who developed minimal pain, mild erythema and post-inflammatory hyperpigmentation during topical photodynamic therapy (PDT) with aminolevulinic acid [dosages not stated]. Case 1: A 17-year-old boy developed pain during PDT with aminolevulinic acid. The boy had a diagnosis of acne vulgaris. Initially, he was treated with numerous topical and oral retinoids, and antibiotics, but these did not improve his condition. Thereafter, he received PDT with aminolevulinic acid. Subsequently, a facial improvement was observed. However, during PDT, he complained about minimal pain, which resolved after the PDT session completion [duration of treatment to reaction onset not stated]. Case 2: A 25-year-woman developed mild erythema, post- inflammatory hyperpigmentation and minimal pain during PDT with aminolevulinic acid. The woman had a diagnosis of facial flat warts (FFW). Initially, she was treated with numerous retinoids and imiquimod, but these did not improve her condition. Thereafter, she received PDT with aminolevulinic acid. During the PDT session, she complained about minimal pain, and after PDT session, a mild erythema and post- inflammatory hyperpigmentation was observed. She was advised to avoid the sun exposure. At the 6 months follow up, hyperpigmentation was improved and at the completion of third PDT session, she completely recovered [duration of treatment to reaction onset not stated]. Author comment: "Common side effects of PDT include erythema, swelling, itching, hyperpigmentation post phototherapy and pain during irradiation." Theresia C, et al. Topical ALA-PDT as alternative therapeutic option in treatment- recalcitrant dermatosis: Report of 4 cases. Photodiagnosis and Photodynamic Therapy 20: 189-192, 17 Oct 2017. Available from: URL: j.pdpdt.2017.10.010 - China 803284432 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals

Aminolevulinic acid

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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