Int Urol Nephrol (2017) 49:1545–1560 DOI 10.1007/s11255-017-1636-5 UROLOGY - ORIGINAL PAPER Ameliorative effect of omega‑3 on spermatogenesis, testicular antioxidant status and preimplantation embryo development in streptozotocin‑induced diabetes in rats 1 1 2 2 Mehdi Khavarimehr · Vahid Nejati · Mazdak Razi · Gholamreza Najafi Received: 21 January 2017 / Accepted: 3 June 2017 / Published online: 16 June 2017 © Springer Science+Business Media B.V. 2017 Abstract (p < 0.05) down-regulation in caspase-3 expression com- Purpose The present study was done to determine the pared to non-treated diabetic rats. Moreover, the omega-3 ameliorative effect of polyunsaturated fatty acid omega-3 maintained DNA integrity, improved sperm quality as well against experimental diabetes-induced damages on testicu- as preimplantation embryo development. lar tissue, sperm parameters and preimplantation embryo Conclusion Our data showed that the omega-3 (espe- −1 development in rat model. cially at 600 mg kg dose level) effectively ameliorates Methods Thirty-two mature male rats were divided into the experimental diabetes-induced infertility in rats by up- two control and test groups. The experimental diabe- regulating the testicular endocrine and antioxidant statuses, −1 tes (50 mg kg streptozotocin, ip) was induced in test preventing mitochondria-dependent apoptosis pathway and group and subdivided into non-treated diabetic, 300
International Urology and Nephrology – Springer Journals
Published: Jun 16, 2017
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