Ambient and Traffic-Related Air Pollution Exposures as Novel Risk Factors for Metabolic Dysfunction and Type 2 Diabetes

Ambient and Traffic-Related Air Pollution Exposures as Novel Risk Factors for Metabolic... Purpose of Review Diabetes mellitus is a top contributor to the global burden of mortality and disability in adults. There has also been a slow but steady rise in prediabetes and type 2 diabetes in youth. The current review summarizes recent findings regarding the impact of increased exposure to air pollutants on the type 2 diabetes epidemic. Recent Findings Human and animal studies provide strong evidence that exposures to ambient and traffic-related air pollutants such as particulate matter (PM), nitrogen dioxide (NO ), and nitrogen oxides (NO ) play an important role in metabolic 2 x dysfunction and type 2 diabetes etiology. This work is supported by recent findings that have observed similar effect sizes for increased exposure to air pollutants on clinical measures of risk for type 2 diabetes in children and adults. Further, studies indicate that these effects may be more pronounced among individuals with existing risk factors, including obesity and prediabetes. Summary Current epidemiological evidence suggests that increased air pollution exposure contributes to alterations in insulin signaling, glucose metabolism, and beta (β)-cell function. Future work is needed to identify the specific detrimental pollutants that alter glucose metabolism. Additionally, advanced tools and new areas of investigation present http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Epidemiology Reports Springer Journals

Ambient and Traffic-Related Air Pollution Exposures as Novel Risk Factors for Metabolic Dysfunction and Type 2 Diabetes

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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Epidemiology
eISSN
2196-2995
D.O.I.
10.1007/s40471-018-0140-5
Publisher site
See Article on Publisher Site

Abstract

Purpose of Review Diabetes mellitus is a top contributor to the global burden of mortality and disability in adults. There has also been a slow but steady rise in prediabetes and type 2 diabetes in youth. The current review summarizes recent findings regarding the impact of increased exposure to air pollutants on the type 2 diabetes epidemic. Recent Findings Human and animal studies provide strong evidence that exposures to ambient and traffic-related air pollutants such as particulate matter (PM), nitrogen dioxide (NO ), and nitrogen oxides (NO ) play an important role in metabolic 2 x dysfunction and type 2 diabetes etiology. This work is supported by recent findings that have observed similar effect sizes for increased exposure to air pollutants on clinical measures of risk for type 2 diabetes in children and adults. Further, studies indicate that these effects may be more pronounced among individuals with existing risk factors, including obesity and prediabetes. Summary Current epidemiological evidence suggests that increased air pollution exposure contributes to alterations in insulin signaling, glucose metabolism, and beta (β)-cell function. Future work is needed to identify the specific detrimental pollutants that alter glucose metabolism. Additionally, advanced tools and new areas of investigation present

Journal

Current Epidemiology ReportsSpringer Journals

Published: Apr 10, 2018

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