Alternative splicing landscape of the Drosophila melanogaster genome

Alternative splicing landscape of the Drosophila melanogaster genome Alternative splicing (AS) intensity (isoform number per gene) was studied as dependent on the gene size for various regions of the Drosophila melanogaster genome. The AS intensity of long transcripts from regions with a low gene density proved to be significantly higher than for regions with a high gene density. An opposite pattern was observed for small genes. The intron density distribution was approximated using the Γ distributions for regions with a high or low gene density. Statistical comparisons of the γ distributions confirmed a lower coefficient λ for regions with a low gene density (i.e., the average intron density was higher). Based on these data, relaxed evolution of the exon-intron structure was assumed for regions with a low gene density. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Alternative splicing landscape of the Drosophila melanogaster genome

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Publisher
SP MAIK Nauka/Interperiodica
Copyright
Copyright © 2010 by Pleiades Publishing, Ltd.
Subject
Biomedicine; Microbial Genetics and Genomics; Animal Genetics and Genomics; Human Genetics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1134/S1022795410090048
Publisher site
See Article on Publisher Site

Abstract

Alternative splicing (AS) intensity (isoform number per gene) was studied as dependent on the gene size for various regions of the Drosophila melanogaster genome. The AS intensity of long transcripts from regions with a low gene density proved to be significantly higher than for regions with a high gene density. An opposite pattern was observed for small genes. The intron density distribution was approximated using the Γ distributions for regions with a high or low gene density. Statistical comparisons of the γ distributions confirmed a lower coefficient λ for regions with a low gene density (i.e., the average intron density was higher). Based on these data, relaxed evolution of the exon-intron structure was assumed for regions with a low gene density.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Sep 30, 2010

References

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