Neuroradiology (2017) 59:905–914 DOI 10.1007/s00234-017-1881-4 FUNCTIONAL NEURORADIOLOGY Altered dynamic functional connectivity in the default mode network in patients with cirrhosis and minimal hepatic encephalopathy 1 1 2 2 Hua-Jun Chen & Hai-Long Lin & Qiu-Feng Chen & Peng-Fei Liu Received: 9 January 2017 /Accepted: 4 July 2017 /Published online: 13 July 2017 Springer-Verlag GmbH Germany 2017 Abstract the PCC/PCUN and bilateral MTL/bilateral LTC; left IPL and Purpose Abnormal brain intrinsic functional connectivity left MTL/bilateral LTC/MPFC; and left LTC and right LTC. (FC) has been documented in minimal hepatic encephalopa- Altered connectivities from state 1 were correlated with pa- thy (MHE) by static connectivity analysis. However, changes tient cognitive performance. Similar findings were observed in dynamic FC (dFC) remain unknown. We aimed to identify when the number of clusters was set to 3 or 4. altered dFC within the default mode network (DMN) associ- Conclusion Aberrant dynamic DMN connectivity is an addi- ated with MHE. tional characteristic of MHE. Dynamic connectivity analysis Methods Resting-state functional MRI data were acquired offers a novel paradigm for understanding MHE-related from 20 cirrhotic patients with MHE and 24 healthy controls. mechanisms. DMN seed regions were defined using seed-based FC analysis (centered on the posterior
Neuroradiology 0028-3940 – Springer Journals
Published: Jul 13, 2017
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