Alterations of Gefitinib Pharmacokinetics by Co-administration of Herbal Medications in Rats

Alterations of Gefitinib Pharmacokinetics by Co-administration of Herbal Medications in Rats • • Chin J Integr Med 2018 Jun;24(6):460-466 Available online at link.springer.com/journal/11655 hinese Journal of Integrative Medicine Journal homepage: www.cjim.cn/zxyjhen/zxyjhen/ch/index.aspx E-mail: cjim_en@cjim.cn Herb-Drug Interaction Alterations of Gefi tinib Pharmacokinetics by Co-administration of Herbal Medications in Rats 1 2 3 2 1 1 Kwon-Yeon Weon , Min Gi Kim , Soyoung Shin , Tae Hwan Kim , Sang Hoon Joo , Eunsook Ma , 1 2 2 2 Seok Won Jeong , Sun Dong Yoo , Yu Seok Youn , and Beom Soo Shin A ABSTRACT BSTRACT O Objective bjective:: To evaluate the potential pharmacokinetic interactions of the anticancer agent ge To evaluate the potential pharmacokinetic interactions of the anticancer agent gefi fi tinib tinib ( (Iressa Iressa )) and the oriental medications Guipi Decoction ( and the oriental medications Guipi Decoction (归 归脾汤 脾汤,, GPD, Guibi-tang in Korean) and Bawu Decoction GPD, Guibi-tang in Korean) and Bawu Decoction ( (八八物汤 物汤, BWD, Palmul-tang in Korean). , BWD, Palmul-tang in Korean). M Methods ethods:: Methylcellulose (MC, control), GPD (1,200 mg/kg), or BWD Methylcellulose (MC, control), GPD (1,200 mg/kg), or BWD ((6,000 mg/kg) was orally administered to rats either as a single dose or multiple doses prior to gefitinib 6,000 mg/kg) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Chinese Journal of Integrative Medicine Springer Journals

Alterations of Gefitinib Pharmacokinetics by Co-administration of Herbal Medications in Rats

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2018 by Chinese Association of the Integration of Traditional and Western Medicine
Subject
Medicine & Public Health; Medicine/Public Health, general
ISSN
1672-0415
eISSN
1993-0402
D.O.I.
10.1007/s11655-017-2907-9
Publisher site
See Article on Publisher Site

Abstract

• • Chin J Integr Med 2018 Jun;24(6):460-466 Available online at link.springer.com/journal/11655 hinese Journal of Integrative Medicine Journal homepage: www.cjim.cn/zxyjhen/zxyjhen/ch/index.aspx E-mail: cjim_en@cjim.cn Herb-Drug Interaction Alterations of Gefi tinib Pharmacokinetics by Co-administration of Herbal Medications in Rats 1 2 3 2 1 1 Kwon-Yeon Weon , Min Gi Kim , Soyoung Shin , Tae Hwan Kim , Sang Hoon Joo , Eunsook Ma , 1 2 2 2 Seok Won Jeong , Sun Dong Yoo , Yu Seok Youn , and Beom Soo Shin A ABSTRACT BSTRACT O Objective bjective:: To evaluate the potential pharmacokinetic interactions of the anticancer agent ge To evaluate the potential pharmacokinetic interactions of the anticancer agent gefi fi tinib tinib ( (Iressa Iressa )) and the oriental medications Guipi Decoction ( and the oriental medications Guipi Decoction (归 归脾汤 脾汤,, GPD, Guibi-tang in Korean) and Bawu Decoction GPD, Guibi-tang in Korean) and Bawu Decoction ( (八八物汤 物汤, BWD, Palmul-tang in Korean). , BWD, Palmul-tang in Korean). M Methods ethods:: Methylcellulose (MC, control), GPD (1,200 mg/kg), or BWD Methylcellulose (MC, control), GPD (1,200 mg/kg), or BWD ((6,000 mg/kg) was orally administered to rats either as a single dose or multiple doses prior to gefitinib 6,000 mg/kg)

Journal

Chinese Journal of Integrative MedicineSpringer Journals

Published: Jan 15, 2018

References

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