• • Chin J Integr Med 2018 Jun;24(6):460-466 Available online at link.springer.com/journal/11655 hinese Journal of Integrative Medicine Journal homepage: www.cjim.cn/zxyjhen/zxyjhen/ch/index.aspx E-mail: email@example.com Herb-Drug Interaction Alterations of Geﬁ tinib Pharmacokinetics by Co-administration of Herbal Medications in Rats 1 2 3 2 1 1 Kwon-Yeon Weon , Min Gi Kim , Soyoung Shin , Tae Hwan Kim , Sang Hoon Joo , Eunsook Ma , 1 2 2 2 Seok Won Jeong , Sun Dong Yoo , Yu Seok Youn , and Beom Soo Shin A ABSTRACT BSTRACT O Objective bjective:: To evaluate the potential pharmacokinetic interactions of the anticancer agent ge To evaluate the potential pharmacokinetic interactions of the anticancer agent geﬁ ﬁ tinib tinib ( (Iressa Iressa )) and the oriental medications Guipi Decoction ( and the oriental medications Guipi Decoction (归 归脾汤 脾汤,, GPD, Guibi-tang in Korean) and Bawu Decoction GPD, Guibi-tang in Korean) and Bawu Decoction ( (八八物汤 物汤, BWD, Palmul-tang in Korean). , BWD, Palmul-tang in Korean). M Methods ethods:: Methylcellulose (MC, control), GPD (1,200 mg/kg), or BWD Methylcellulose (MC, control), GPD (1,200 mg/kg), or BWD ((6,000 mg/kg) was orally administered to rats either as a single dose or multiple doses prior to gefitinib 6,000 mg/kg)
Chinese Journal of Integrative Medicine – Springer Journals
Published: Jan 15, 2018
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