Human cytomegalovirus infection of human umbilical vein endothelial cells reduces the ability of these cells to bind to fibronectin, collagen type IV and laminin. This suppression requires active virus, since UV-inactivated virus did not alter the binding ability of these cells to adhere to fibronectin, collagen type IV, and laminin. In an attempt to elucidate the molecular mechanism of this altered interaction, the surface expression of α5β1, α2β1, α3β1, and α6β1 integrins on cytomegalovirus-infected endothelial cells was examined using attachment inhibition assay and flow cytometric analysis. The results presented here show that infection with human cytomegalovirus selectively alters the expression of integrin on human endothelial cells, with the ability to induce downregulation of α5β1 and α2β1 (p=0.001 and p=0.03, respectively), while significantly upregulating α6β1 (p=0.03), and marginally upregulating α3β1 (p=0.05).
Archives of Virology – Springer Journals
Published: Jan 1, 1997
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