Alpha-tocopherol and ginkgo biloba treatment protects lipid peroxidation during ischemic period in rat groin island skin flaps

Alpha-tocopherol and ginkgo biloba treatment protects lipid peroxidation during ischemic period... Oxygen-derived free radicals have been implicated in the causation of cellular injury during low-flow ischemia and during reperfusion of previously completely ischemic tissue; they are also believed to be the causative factor in the no-reflow phenomena. Modulation of these free radical substances has been suggested as a means of decreasing the amount of tissue loss due to ischemia and subsequent reperfusion. Pretreatment of tissues with a variety of agents has been reported to minimize the production of oxygen radicals and augment tissue survival after an ischemic insult. Further evidence of free radical involvement in skin flap necrosis in a rat groin island skin flap model is presented. In addition, the effects of two different free radical scavengers, alpha tocopherol (20 mg/kg intraperitoneally once daily for a week) and ginkgo biloba (5 mg/kg orally twice a day for a week) have been investigated and compared. Since malonyldialdehyde (MDA) is the end product of lipoperoxidation which occurs in cellular membranes in an ischemic period - dependent manner, MDA levels in tissue homogenates were measured 60, 90, and 120 min after an ischemic insult. MDA levels significantly increased in a time-dependent manner during the ischemic period in the control group. Results from the determination of tissue MDA levels at biopsy sites of radical scavenger treated groups compared with the placebo group showed that the ginkgo biloba-treated rat samples had significantly lower MDA levels than control samples only at the 120 min ischemic period ( p <0.01). However, protection of lipoperoxidation in alpha tocopherol-treated rat samples was detected after both the 90 and 12 min ischemic periods ( p <0.01), and the magnitude of these decreased MDA levels in alpha tocopherol-treated samples was found to be greater than it was after ginkgo biloba treatment. Decreasing free radicals during reperfusion by using these agents, preferably alpha tocopherol, may be beneficial in modulating the no-reflow phenomenon and subsequent reperfusion injury, and may help to improve tissue salvage. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Plastic Surgery Springer Journals

Alpha-tocopherol and ginkgo biloba treatment protects lipid peroxidation during ischemic period in rat groin island skin flaps

Loading next page...
 
/lp/springer_journal/alpha-tocopherol-and-ginkgo-biloba-treatment-protects-lipid-pTzyx1xk7W
Publisher
Springer-Verlag
Copyright
Copyright © 1997 by Springer-Verlag
Subject
Medicine & Public Health; Plastic Surgery
ISSN
0930-343X
eISSN
1435-0130
D.O.I.
10.1007/BF01002048
Publisher site
See Article on Publisher Site

References

  • Hydroperoxide metabolism in mammalian organs
    Chance, B; Sies, H; Bovouis, A

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial