Oxygen-derived free radicals have been implicated in the causation of cellular injury during low-flow ischemia and during reperfusion of previously completely ischemic tissue; they are also believed to be the causative factor in the no-reflow phenomena. Modulation of these free radical substances has been suggested as a means of decreasing the amount of tissue loss due to ischemia and subsequent reperfusion. Pretreatment of tissues with a variety of agents has been reported to minimize the production of oxygen radicals and augment tissue survival after an ischemic insult. Further evidence of free radical involvement in skin flap necrosis in a rat groin island skin flap model is presented. In addition, the effects of two different free radical scavengers, alpha tocopherol (20 mg/kg intraperitoneally once daily for a week) and ginkgo biloba (5 mg/kg orally twice a day for a week) have been investigated and compared. Since malonyldialdehyde (MDA) is the end product of lipoperoxidation which occurs in cellular membranes in an ischemic period - dependent manner, MDA levels in tissue homogenates were measured 60, 90, and 120 min after an ischemic insult. MDA levels significantly increased in a time-dependent manner during the ischemic period in the control group. Results from the determination of tissue MDA levels at biopsy sites of radical scavenger treated groups compared with the placebo group showed that the ginkgo biloba-treated rat samples had significantly lower MDA levels than control samples only at the 120 min ischemic period ( p <0.01). However, protection of lipoperoxidation in alpha tocopherol-treated rat samples was detected after both the 90 and 12 min ischemic periods ( p <0.01), and the magnitude of these decreased MDA levels in alpha tocopherol-treated samples was found to be greater than it was after ginkgo biloba treatment. Decreasing free radicals during reperfusion by using these agents, preferably alpha tocopherol, may be beneficial in modulating the no-reflow phenomenon and subsequent reperfusion injury, and may help to improve tissue salvage.
European Journal of Plastic Surgery – Springer Journals
Published: May 1, 1997
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.
All for just $49/month
Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.
Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.
It’s easy to organize your research with our built-in tools.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera