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Alpha-Fetoprotein in Retina and Lens of the Human Eye at Early Stages of Prenatal Development

Alpha-Fetoprotein in Retina and Lens of the Human Eye at Early Stages of Prenatal Development The presence of alpha-fetoprotein (AFP) was shown in the retina and lens of the human fetal eye at different stages of prenatal development. PCR analysis revealed AFP mRNA neither in the retina nor in the lens, whereas in the fetal liver (control) AFP mRNA was found to be expressed. The data obtained indicate that AFP is not synthesized in retinal and lens cells of the human fetal eye but is imported from elsewhere to be taken up by these cells. The presence of AFP in the retina and lens implies its involvement in early morphogenesis and differentiation of these ocular tissues during prenatal human development. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Evolutionary Biochemistry and Physiology Springer Journals

Alpha-Fetoprotein in Retina and Lens of the Human Eye at Early Stages of Prenatal Development

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Pleiades Publishing, Ltd.
Subject
Life Sciences; Evolutionary Biology; Biochemistry, general; Animal Physiology
ISSN
0022-0930
eISSN
1608-3202
DOI
10.1134/S0022093018020047
Publisher site
See Article on Publisher Site

Abstract

The presence of alpha-fetoprotein (AFP) was shown in the retina and lens of the human fetal eye at different stages of prenatal development. PCR analysis revealed AFP mRNA neither in the retina nor in the lens, whereas in the fetal liver (control) AFP mRNA was found to be expressed. The data obtained indicate that AFP is not synthesized in retinal and lens cells of the human fetal eye but is imported from elsewhere to be taken up by these cells. The presence of AFP in the retina and lens implies its involvement in early morphogenesis and differentiation of these ocular tissues during prenatal human development.

Journal

Journal of Evolutionary Biochemistry and PhysiologySpringer Journals

Published: Jun 4, 2018

References