Allogeneic Reduced-Intensity Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease: a Single-Center Prospective Trial

Allogeneic Reduced-Intensity Hematopoietic Stem Cell Transplantation for Chronic Granulomatous... J Clin Immunol (2017) 37:548–558 DOI 10.1007/s10875-017-0422-6 ORIGINAL ARTICLE Allogeneic Reduced-Intensity Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease: a Single-Center Prospective Trial 1 2 2 2 2 Mark Parta & Corin Kelly & Nana Kwatemaa & Narda Theobald & Diane Hilligoss & 3 4 5 5,6 2 Jing Qin & Douglas B. Kuhns & Christa Zerbe & Steven M. Holland & Harry Malech & Elizabeth M. Kang Received: 20 February 2017 /Accepted: 13 July 2017 /Published online: 28 July 2017 US Government (outside the USA) 2017 Abstract dose total body irradiation for MUD recipients) with sirolimus Purpose The purpose of this study was to evaluate engraft- graft-versus-host disease prophylaxis. ment and adverse events with a conditioning and prophylactic Results Engraftment occured in 38/40 recipients (95%). Acute regimen intended to achieve high rates of engraftment with or chronic GVHD occurred in 18 (45%) and 5 (12.5%), respec- minimal graft-versus-host disease (GVHD) in allogeneic tively, with 6 episodes of grades III–IVand/or steroid refractory transplantation for chronic granulomatous disease in a single GVHD. Overall survival was 33/40 (82.5%) and event-free sur- center. vival was 30/40 (80%). Successful engraftment was associated Methods Forty patients, 37 male, with chronic granulomatous with myeloid and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Clinical Immunology Springer Journals

Allogeneic Reduced-Intensity Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease: a Single-Center Prospective Trial

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Publisher
Springer US
Copyright
Copyright © 2017 by US Government (outside the USA)
Subject
Biomedicine; Immunology; Infectious Diseases; Internal Medicine; Medical Microbiology
ISSN
0271-9142
eISSN
1573-2592
D.O.I.
10.1007/s10875-017-0422-6
Publisher site
See Article on Publisher Site

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