Curr Treat Options Allergy (2018) 5:140–153
Contact Dermatitis (M Gonçalo, Section Editor)
Allergic Contact Dermatitis:
I. Poveda-Montoyo, MD
P. J. A
J. F. Silvestre, MD
Dermatology Department, Instituto de Investigación Sanitaria y Biomédica de
Alicante (ISABIAL), Hospital General Universitario de Alicante, Alicante, Spain
Published online: 25 January 2018
* Springer International Publishing AG, part of Springer Nature 2018
This article is part of the Topical Collection on Contact Dermatitis
Keywords Allergen avoidance
Allergic contact dermatitis
Purpose of Review Allergic contact dermatitis (ACD) is a common condition and may entail
negative impacts on people’s quality of life along with a substantial economic burden.
Appropriately managing it through patient education, allergen avoidance, and symptom-
atic treatment is crucial for its resolution. Our review aims to establish a practical approach
to ACD management, based on a comprehensive discussion of available therapeutic
options for ACD, a review of the latest findings in this field, and personal insights from
our clinical practice experience.
Recent Findings Topical treatments constitute the first-line therapy for ACD. Randomized
clinical trials have shown topical corticosteroids to improve clinical and nonclinical
outcomes, while tacrolimus has proven effective and safe. Evidence is lacking for oral
corticosteroids in ACD sufferers, so recommendations for its use are primarily based on
results obtained in dermatitis of other etiologies. In contrast, some studies have assessed
azathioprine and phototherapy for ACD.
Summary Patient education and allergen avoidance are paramount for managing ACD.
However, individualized symptomatic treatment is warranted in several clinical situations.
Although these treatments are widely used in clinical practice, few studies support their
use for ACD. Further research is needed.
Allergic contact dermatitis (ACD) is a delayed hypersen-
sitivity reaction to one or more chemical substances
found in the patient’s personal or work environment.
This commonly diagnosed entity accounts for approxi-
mately 20% of cases of contact dermatitis [1••], and is
estimated to affect between 10 and 27% of the European