Allele Polymorphism of the Serotonin Transporter Gene and Clinical Heterogeneity of Depressions

Allele Polymorphism of the Serotonin Transporter Gene and Clinical Heterogeneity of Depressions Depression disorders are a clinically heterogeneous disease group. Their development is to a substantial extent underlain by dysfunction of the serotonin system, in particular, disturbed serotonin transport. The heterogeneity of depressions is associated, among other factors, with the age at disease onset. Allele polymorphism of the serotonin transporter (5-HTT) gene was tested for association with age at disease onset, clinical signs, and anxiety-related traits of depression patients. A sample included 77 patients (mean age 61.2 ± 8.8 years) with late-onset depression (LOD, mean age at onset 56.58 ± 9.7 years) and 74 patients (mean age 31.0 ± 11.8 years) with early-onset depression (EOD, mean age at onset 23.9 ± 7.4 years). In genotype frequency distribution of two 5-HTT gene polymorphisms, the LOD and EOD groups did not differ from each other (χ2 = 0.33, P = 0.85 for VNTR; χ2 = 3.33, P = 0.19 for HTTLPR) and from a control group (χ2 = 0.34,P = 0.84 for VNTR; χ2 = 2.1, P= 0.35 for HTTLPR). In either group, patients differing in VNTR and HTTLPR genotypes did not differ in psychological traits and, in particular, in anxiety-related traits. In the case of the HTTLPR polymorphism, LOD patients with genotype sstended to display less severe neuroticism (t= 2.03, P = 0.0507) and scored significantly less on the Hamilton depression scale (t = 2.19, P = 0.039). Thus, the 5-HTT gene polymorphisms do not affect the risk of depression but is possibly associated with specific clinical signs of the disease, at least in elderly patients. Russian Journal of Genetics Springer Journals

Allele Polymorphism of the Serotonin Transporter Gene and Clinical Heterogeneity of Depressions

Loading next page...
Kluwer Academic Publishers-Plenum Publishers
Copyright © 2002 by MAIK “Nauka/Interperiodica”
Biomedicine; Human Genetics
Publisher site
See Article on Publisher Site


You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial