Keywords Alkynylation Zinc Propargylic alcohol a-Tertiary-hydroxy ester a- Alkynyl alcohol Introduction Propargylic alcohols are versatile precursors for the synthesis of natural products and pharmaceutically relevant compounds [1–3]. Especially, they can be trans- formed to important carbocycles and heterocycles such as 1H-indenes , pyrazoles & Wen-Cai Huang email@example.com Department of Pharmaceutical and Bioengineering, School of Chemical Engineering, Sichuan University, Chengdu 610065, People’s Republic of China 123 4284 J.-C. Zhou et al. , isoxazoles , tetrazoles , benzofurans  and b-lactams . Different processes have been developed to prepare structurally diverse propargylic alcohols over the past decades, among which alkynylation of aldehydes is a straightforward and very useful method [10–16]. In most cases, organometallic reagents such as diethylzinc [17–21], dimethylzinc [22–24] and n-butyllithium [25, 26] are needed to abstract the active hydrogen of terminal alkynes to form metal acetylides, followed by nucleophilic addition to aldehydes to afford propargylic alcohols. However, there are some recognized limitations of this approach because these alkylmetal reagents are sensitive toward air and moisture and thus inconvenient to handle. Recently, some progress has been made in the alkynylation of aldehydes without the use of the strong bases mentioned above. ZnO, a cheap and
Research on Chemical Intermediates – Springer Journals
Published: Feb 7, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera