Alendronic-acid/corticosteroids

Alendronic-acid/corticosteroids Reactions 1704, p22 - 2 Jun 2018 Atypical femoral fractures: case report A 67-year-old woman developed atypical femoral fractures (AFF) following treatment with unspecified corticosteroids [corticotherapy] and alendronic acid [alendronate; route, dosage and time to reaction onset not stated]. The woman, who had osteoporosis and recurrent fractures had been receiving long-term treatment with alendronic acid during 10 years and unspecified corticosteroids. She was referred to rheumatology department due to bilateral thigh pain with major functional difficulty. A bone scintigraphy revealed elevated bilateral femoral cortical tracer uptake, and incomplete cortical AFF was revealed during the radiographic investigation. She was diagnosed with AFF with femoral neck T-score of -2.8. The serum total and bone-specific ALP were low at 34 UI/L and 2.3 µg/L, respectively. Her AFF was considered to be related to long-term treatments with unspecified corticosteroids and alendronic acid. The woman was treated with teriparatide to prevent further fractures and to accelerate the bone consolidation. After 6 months of the treatment, despite of decrease in the pain, a right and left femoral preventive orthopaedic internal fixation was performed. The internal fixation was performed due to the deformation in crook of the left femur that can have impact on consolidation, insufficient improvement in functional difficulty with a waddling gait and persistent activity of the two fractures revealed during bone scintigraphy. A year after the treatment, significant improvement was observed in her functional incapacity and pain. Radiographies revealed callus formation, and her ALP levels were normal. An increase in serum level of C-terminal type 1 collagen telopeptide was observed. Author comment: "Several causes of [atypical femoral fractures] can be discussed in the case of our patient such as the long-term bisphosphonate treatment in the context of adult hypophosphatasia, the long-term corticotherapy and the hip geometry." Righetti M, et al. Teriparatide treatment in an adult patient with hypophosphatasia exposed to bisphosphonate and revealed by bilateral atypical fractures. Joint Bone Spine 85: 365-367, No. 3, May 2018. Available from: URL: http://doi.org/10.1016/ j.jbspin.2017.12.001 - France 803324025 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Alendronic-acid/corticosteroids

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46665-6
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p22 - 2 Jun 2018 Atypical femoral fractures: case report A 67-year-old woman developed atypical femoral fractures (AFF) following treatment with unspecified corticosteroids [corticotherapy] and alendronic acid [alendronate; route, dosage and time to reaction onset not stated]. The woman, who had osteoporosis and recurrent fractures had been receiving long-term treatment with alendronic acid during 10 years and unspecified corticosteroids. She was referred to rheumatology department due to bilateral thigh pain with major functional difficulty. A bone scintigraphy revealed elevated bilateral femoral cortical tracer uptake, and incomplete cortical AFF was revealed during the radiographic investigation. She was diagnosed with AFF with femoral neck T-score of -2.8. The serum total and bone-specific ALP were low at 34 UI/L and 2.3 µg/L, respectively. Her AFF was considered to be related to long-term treatments with unspecified corticosteroids and alendronic acid. The woman was treated with teriparatide to prevent further fractures and to accelerate the bone consolidation. After 6 months of the treatment, despite of decrease in the pain, a right and left femoral preventive orthopaedic internal fixation was performed. The internal fixation was performed due to the deformation in crook of the left femur that can have impact on consolidation, insufficient improvement in functional difficulty with a waddling gait and persistent activity of the two fractures revealed during bone scintigraphy. A year after the treatment, significant improvement was observed in her functional incapacity and pain. Radiographies revealed callus formation, and her ALP levels were normal. An increase in serum level of C-terminal type 1 collagen telopeptide was observed. Author comment: "Several causes of [atypical femoral fractures] can be discussed in the case of our patient such as the long-term bisphosphonate treatment in the context of adult hypophosphatasia, the long-term corticotherapy and the hip geometry." Righetti M, et al. Teriparatide treatment in an adult patient with hypophosphatasia exposed to bisphosphonate and revealed by bilateral atypical fractures. Joint Bone Spine 85: 365-367, No. 3, May 2018. Available from: URL: http://doi.org/10.1016/ j.jbspin.2017.12.001 - France 803324025 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

References

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