Aggregation of magnetic chitosan based nanoparticles and their application in controlled drug release

Aggregation of magnetic chitosan based nanoparticles and their application in controlled drug... Novel less than 100 nm sized magnetic Co0.5Mn0.5Fe2O4-chitosan nanoparticles advantageous in respect of excellent biodegradation and high level of controllability are successfully prepared. TEM and SEM images showed the cubic-shape magnetic Co0.5Mn0.5Fe2O4 particles were encapsulated by spherical chitosan nanoparticles. The release behavior of bovine serum albumin entrapped in the particles was of distinctly difference with the changes of pH value of loading medium. The release of bovine serum albumin in those two kinds of particles in the medium of pH=1.0 was much quicker in pH = 7.4 and 9.18. The amount of Bovine serum albumin (BSA) released from the particles at different time intervals was estimated using UV spectrophotomertic method at 279 nm. The dissolution profile and in vitro release kinetics showed that Co0.5Mn0.5Fe2O4-chitosan nanoparticles were promising for controlled delivery of the drug. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Applied Chemistry Springer Journals

Aggregation of magnetic chitosan based nanoparticles and their application in controlled drug release

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Publisher
Pleiades Publishing
Copyright
Copyright © 2015 by Pleiades Publishing, Ltd.
Subject
Chemistry; Chemistry/Food Science, general; Industrial Chemistry/Chemical Engineering
ISSN
1070-4272
eISSN
1608-3296
D.O.I.
10.1134/S1070427215030246
Publisher site
See Article on Publisher Site

Abstract

Novel less than 100 nm sized magnetic Co0.5Mn0.5Fe2O4-chitosan nanoparticles advantageous in respect of excellent biodegradation and high level of controllability are successfully prepared. TEM and SEM images showed the cubic-shape magnetic Co0.5Mn0.5Fe2O4 particles were encapsulated by spherical chitosan nanoparticles. The release behavior of bovine serum albumin entrapped in the particles was of distinctly difference with the changes of pH value of loading medium. The release of bovine serum albumin in those two kinds of particles in the medium of pH=1.0 was much quicker in pH = 7.4 and 9.18. The amount of Bovine serum albumin (BSA) released from the particles at different time intervals was estimated using UV spectrophotomertic method at 279 nm. The dissolution profile and in vitro release kinetics showed that Co0.5Mn0.5Fe2O4-chitosan nanoparticles were promising for controlled delivery of the drug.

Journal

Russian Journal of Applied ChemistrySpringer Journals

Published: Jun 25, 2015

References

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