Age Dynamics of Adult Fly Activity in Drosophila Strains with Apoptosis Deregulation after Larval Exposure to Chronic Irradiation

Age Dynamics of Adult Fly Activity in Drosophila Strains with Apoptosis Deregulation after Larval... The relationship was studied between radiation-induced apoptosis in the nervous system of Drosophila larvae and the age dynamics in adult fly neuromuscular activity. The level of apoptosis in the neural ganglia of third-instar larvae from the wild-type strain increased 2.5 times after larval exposure to ionizing radiation (54 cGy). Irradiation of the strain with enhanced sensitivity to apoptosis induction, which carries a mutation in gene–inhibitor of apoptosis th (allele th 4), and the wild-type strain Berlin led to an increase in neuromuscular activity of adult flies throughout the experiment and, consequently, to reduced aging rate. Conversely, this effect was not observed in strains with reduced sensitivity to induction of apoptosis (with mutations in genes dArk and Dcp-1). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Age Dynamics of Adult Fly Activity in Drosophila Strains with Apoptosis Deregulation after Larval Exposure to Chronic Irradiation

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Publisher
Kluwer Academic Publishers-Plenum Publishers
Copyright
Copyright © 2004 by MAIK “Nauka/Interperiodica”
Subject
Biomedicine; Human Genetics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1023/B:RUGE.0000016998.21255.45
Publisher site
See Article on Publisher Site

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