as a recyclable catalyst for the facile green
synthesis of 3-methyl-4-(phenyl)methylene-isoxazole-
Surya Narayana Maddila
Werner E. van Zyl
Sreekantha B. Jonnalagadda
Received: 10 April 2015 / Accepted: 4 July 2015 / Published online: 15 July 2015
Ó Springer Science+Business Media Dordrecht 2015
An efﬁcient and facile green method for synthesis of 3-methyl-4-(phe-
nyl)methylene-isoxazole-5(4H)-one (4a-m) via room temperature reaction of hydroxy-
lamine, ethylacetoacetate and substituted aromatic aldehydes is designed, using Ag/SiO
as catalyst with water as solvent. This protocol offers several advantages, such as it being
a benign, energy conserving and eco-friendly reaction with products obtained in
excellent yields (88–93 %). The reaction requires relatively short reaction times (\1 h),
a simple workup procedure with good atom efﬁciency and easily recoverable catalyst.
The heterogeneous catalyst, Ag/SiO
, was fully characterized and is reusable without
loss of activity for up to seven cycles with marginal activity loss.
Electronic supplementary material The online version of this article (doi:10.1007/s11164-015-2167-2)
contains supplementary material, which is available to authorized users.
& Sreekantha B. Jonnalagadda
School of Chemistry and Physics, University of KwaZulu-Natal, Westville Campus,
Chiltern Hills, Durban 4000, South Africa
Res Chem Intermed (2016) 42:2553–2566