Aerobic training improves platelet function in type 2 diabetic patients: role of microRNA-130a and GPIIb

Aerobic training improves platelet function in type 2 diabetic patients: role of microRNA-130a... Aims MicroRNAs (miRs) that are mediators of gene expression have been implicated in type 2 diabetes mellitus (T2DM). Platelet hyper-reactivity is one of the most important disorders in T2DM patients. In this study, we explored the effects of aerobic training (AT) on platelet aggregation and Glycoprotein IIb (GPIIb) receptor and miR-130a expression. Methods In a quasi-experimental controlled trial, 24 sedentary, eligible female participants with T2DM were selected (age 61.92 ± 3.63) and divided into AT and control (CON) groups based on their peak oxygen consumption (VO ). AT proto- 2peak col was performed three times per week in non-consecutive days on a treadmill with mean intensity (60–75% VO ) for 8 2peak weeks, while the control group refrained from any type of exercise training. Two blood samples were taken before and after this period. Real-time PCR was used to determine the expression of platelet GPIIb and miR-130a. Moreover, platelet indices (PLT, MPV, PDW, and PCT), collagen-induced platelet aggregation and glycemic variables were measured. Results Analyses of data showed that anthropometric variables, VO and glycemic control improved significantly 2peak (P < 0.01) after AT. Furthermore, MPV, PDW (P < 0.01), and platelet aggregation (P < 0.001) decreased significantly fol- lowing http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Diabetologica Springer Journals

Aerobic training improves platelet function in type 2 diabetic patients: role of microRNA-130a and GPIIb

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Publisher
Springer Milan
Copyright
Copyright © 2018 by Springer-Verlag Italia S.r.l., part of Springer Nature
Subject
Medicine & Public Health; Internal Medicine; Diabetes; Metabolic Diseases
ISSN
0940-5429
eISSN
1432-5233
D.O.I.
10.1007/s00592-018-1167-2
Publisher site
See Article on Publisher Site

Abstract

Aims MicroRNAs (miRs) that are mediators of gene expression have been implicated in type 2 diabetes mellitus (T2DM). Platelet hyper-reactivity is one of the most important disorders in T2DM patients. In this study, we explored the effects of aerobic training (AT) on platelet aggregation and Glycoprotein IIb (GPIIb) receptor and miR-130a expression. Methods In a quasi-experimental controlled trial, 24 sedentary, eligible female participants with T2DM were selected (age 61.92 ± 3.63) and divided into AT and control (CON) groups based on their peak oxygen consumption (VO ). AT proto- 2peak col was performed three times per week in non-consecutive days on a treadmill with mean intensity (60–75% VO ) for 8 2peak weeks, while the control group refrained from any type of exercise training. Two blood samples were taken before and after this period. Real-time PCR was used to determine the expression of platelet GPIIb and miR-130a. Moreover, platelet indices (PLT, MPV, PDW, and PCT), collagen-induced platelet aggregation and glycemic variables were measured. Results Analyses of data showed that anthropometric variables, VO and glycemic control improved significantly 2peak (P < 0.01) after AT. Furthermore, MPV, PDW (P < 0.01), and platelet aggregation (P < 0.001) decreased significantly fol- lowing

Journal

Acta DiabetologicaSpringer Journals

Published: May 31, 2018

References

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