Cardiovasc Intervent Radiol (2017) 40:1367–1371 DOI 10.1007/s00270-017-1637-x CLINICAL INVESTIGATI O N V ENOUS I NT ERVENTIONS Adrenal Vein Sampling for Primary Aldosteronism: A 2-Week Protocol for Withdrawal of Renin-Stimulating Antihypertensives 1 2 3 4 • • • Kevin C. Ching Debbie L. Cohen Douglas L. Fraker Scott O. Trerotola Received: 12 January 2017 / Accepted: 22 March 2017 / Published online: 4 April 2017 Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2017 Abstract Measurements Plasma renin activity (PRA) was measured Objective For evaluation of primary aldosteronism, inter- immediately before venous sampling to assess for renin national guidelines recommend a 4–6 week withdrawal of suppression (PRA \ 0.5 ng/ml/hr). Demographics, anti- spironolactone, eplerenone, and amiloride prior to adrenal hypertensive medications, plasma aldosterone, plasma vein sampling (AVS). It is not always feasible to withdraw renin activity, and outcomes were reviewed. these drugs in patients with severe hypertension and hypo- Results 100% of procedures were diagnostic (selectivity kalemia. We present our experience evaluating the efﬁcacy index C 3) and lateralization (lateralization index C 4) and clinical outcomes of a 2-week protocol for withdrawal of was conﬁrmed in 22/32 patients. 19/32 patients had con- renin-stimulating
CardioVascular and Interventional Radiology – Springer Journals
Published: Apr 4, 2017
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