ADC as a useful diagnostic tool for differentiating benign and malignant vertebral bone marrow lesions and compression fractures: a systematic review and meta-analysis

ADC as a useful diagnostic tool for differentiating benign and malignant vertebral bone marrow... Objectives To assess the sensitivity and specificity of quantitative assessment of the apparent diffusion coefficient (ADC) for differentiating benign and malignant vertebral bone marrow lesions (BMLs) and compression fractures (CFs) Methods An electronic literature search of MEDLINE and EMBASE was conducted. Bivariate modelling and hierarchical summary receiver operating characteristic modelling were performed to evaluate the diagnostic performance of ADC for differ- entiating vertebral BMLs. Subgroup analysis was performed for differentiating benign and malignant vertebral CFs. Meta- regression analyses according to subject, study and diffusion-weighted imaging (DWI) characteristics were performed. Results Twelve eligible studies (748 lesions, 661 patients) were included. The ADC exhibited a pooled sensitivity of 0.89 (95% confidence interval [CI] 0.80–0.94) and a pooled specificity of 0.87 (95% CI 0.78–0.93) for differentiating benign and malignant vertebral BMLs. In addition, the pooled sensitivity and specificity for differentiating benign and malignant CFs were 0.92 (95% CI 0.82–0.97) and 0.91 (95% CI 0.87–0.94), respectively. In the meta-regression analysis, the DWI slice thickness was a significant factor affecting heterogeneity (p < 0.01); thinner slice thickness (< 5 mm) showed higher specificity (95%) than thicker slice thickness (81%). Conclusions Quantitative assessment of ADC is a useful diagnostic tool for differentiating benign and malignant http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Radiology Springer Journals

ADC as a useful diagnostic tool for differentiating benign and malignant vertebral bone marrow lesions and compression fractures: a systematic review and meta-analysis

13 pages
Read Article

Loading next page...
 
/lp/springer_journal/adc-as-a-useful-diagnostic-tool-for-differentiating-benign-and-qdAGUVPgyc
Publisher
Springer Journals
Copyright
Copyright © 2018 by European Society of Radiology
Subject
Medicine & Public Health; Imaging / Radiology; Diagnostic Radiology; Interventional Radiology; Neuroradiology; Ultrasound; Internal Medicine
ISSN
0938-7994
eISSN
1432-1084
D.O.I.
10.1007/s00330-018-5330-5
Publisher site
See Article on Publisher Site

Abstract

Objectives To assess the sensitivity and specificity of quantitative assessment of the apparent diffusion coefficient (ADC) for differentiating benign and malignant vertebral bone marrow lesions (BMLs) and compression fractures (CFs) Methods An electronic literature search of MEDLINE and EMBASE was conducted. Bivariate modelling and hierarchical summary receiver operating characteristic modelling were performed to evaluate the diagnostic performance of ADC for differ- entiating vertebral BMLs. Subgroup analysis was performed for differentiating benign and malignant vertebral CFs. Meta- regression analyses according to subject, study and diffusion-weighted imaging (DWI) characteristics were performed. Results Twelve eligible studies (748 lesions, 661 patients) were included. The ADC exhibited a pooled sensitivity of 0.89 (95% confidence interval [CI] 0.80–0.94) and a pooled specificity of 0.87 (95% CI 0.78–0.93) for differentiating benign and malignant vertebral BMLs. In addition, the pooled sensitivity and specificity for differentiating benign and malignant CFs were 0.92 (95% CI 0.82–0.97) and 0.91 (95% CI 0.87–0.94), respectively. In the meta-regression analysis, the DWI slice thickness was a significant factor affecting heterogeneity (p < 0.01); thinner slice thickness (< 5 mm) showed higher specificity (95%) than thicker slice thickness (81%). Conclusions Quantitative assessment of ADC is a useful diagnostic tool for differentiating benign and malignant

Journal

European Radiology – Springer Journals

Published: Feb 15, 2018

References

  • SSH-EPI diffusion-weighted MR imaging of the spine with low b values: is it useful in differentiating malignant metastatic tumor infiltration from benign fracture edema?
    Oztekin, O; Ozan, E; Hilal Adibelli, Z; Unal, G; Abali, Y
  • Differentiation between focal malignant marrow-replacing lesions and benign red marrow deposition of the spine with T2*-corrected fat-signal fraction map using a three-echo volume interpolated breath-hold gradient echo Dixon sequence
    Kim, YP; Kannengiesser, S; Paek, MY
  • Discrimination of metastatic from acute osteoporotic compression spinal fractures with MR imaging
    Jung, HS; Jee, WH; McCauley, TR; Ha, KY; Choi, KH
  • Solitary vertebral collapse: distinction between benign and malignant causes using MR patterns
    Shih, TT; Huang, KM; Li, YW
  • Vertebral metastases: assessment with apparent diffusion coefficient
    Herneth, AM; Philipp, MO; Naude, J
  • Diffusion-weighted MR imaging of bone marrow: differentiation of benign versus pathologic compression fractures
    Baur, A; Stäbler, A; Brüning, R
  • Diffusion-weighted imaging of the spine: is it reliable?
    Castillo, M
  • Diffusion-weighted MR imaging offers no advantage over routine noncontrast MR imaging in the detection of vertebral metastases
    Castillo, M; Arbelaez, A; Smith, JK; Fisher, LL
  • Characterization of benign and metastatic vertebral compression fractures with quantitative diffusion MR imaging
    Zhou, XJ; Leeds, NE; McKinnon, GC; Kumar, AJ
  • Acute vertebral body compression fractures: discrimination between benign and malignant causes using apparent diffusion coefficients
    Chan, JH; Pen, WC; Tsui, EY
  • Optimization of b value in diffusion-weighted MRI for the differential diagnosis of benign and malignant vertebral fractures
    Tang, G; Liu, Y; Li, W; Yao, J; Li, B; Li, P
  • Standard-b-value vs low-b-value DWI for differentiation of benign and malignant vertebral fractures: a meta-analysis
    Luo, Z; Litao, L; Gu, S
  • Research synthesis: what is the diagnostic performance of magnetic resonance imaging to discriminate benign from malignant vertebral compression fractures?
    Thawait, SK; Marcus, MA; Morrison, WB; Klufas, RA; Eng, J; Carrino, JA
  • The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration
    Liberati, A; Altman, DG; Tetzlaff, J
  • QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies
    Whiting, PF; Rutjes, AW; Westwood, ME
  • Successful publication of systematic review and meta-analysis of studies evaluating diagnostic test accuracy
    Suh, CH; Park, SH
  • Systematic review and meta-analysis of studies evaluating diagnostic test accuracy: a practical review for clinical researchers—part I. General guidance and tips
    Kim, KW; Lee, J; Choi, SH; Huh, J; Park, SH
  • Systematic review and meta-analysis of studies evaluating diagnostic test accuracy: a practical review for clinical researchers—part II. Statistical methods of meta-analysis
    Lee, J; Kim, KW; Choi, SH; Huh, J; Park, SH
  • Conducting systematic reviews of diagnostic studies: didactic guidelines
    Deville, WL; Buntinx, F; Bouter, LM
  • The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed
    Deeks, JJ; Macaskill, P; Irwig, L
  • Diagnostic value of apparent diffusion coefficients to differentiate benign from malignant vertebral bone marrow lesions
    Balliu, E; Vilanova, JC; Peláez, I
  • Line scan diffusion imaging of the spine
    Bammer, R; Herneth, AM; Maier, SE
  • Diagnostic value of increased diffusion weighting of a steady-state free precession sequence for differentiating acute benign osteoporotic fractures from pathologic vertebral compression fractures
    Baur, A; Huber, A; Ertl-Wagner, B
  • Diffusion weighted MR imaging in acute vertebral compression fractures: differentiation between malignant and benign causes
    Bhugaloo, A; Abdullah, B; Siow, Y; Ng, K
  • Combined diffusion-weighted and dynamic contrast-enhanced imaging of patients with acute osteoporotic vertebral fractures
    Biffar, A; Sourbron, S; Dietrich, O
  • Physiological background of differences in quantitative diffusion-weighted magnetic resonance imaging between acute malignant and benign vertebral body fractures: correlation of apparent diffusion coefficient with quantitative perfusion magnetic resonance imaging using the 2-compartment exchange model
    Geith, T; Biffar, A; Schmidt, G
  • Influence of lesion ratio on diagnostic performance of in-phase/opposed-phase imaging and apparent diffusion coefficient for differentiating acute benign vertebral fractures and metastases
    Lin, F; Lei, Y; Li, YB
  • Quantitative assessment of diffusion abnormalities in benign and malignant vertebral compression fractures by line scan diffusion-weighted imaging
    Maeda, M; Sakuma, H; Maier, SE; Takeda, K
  • Accuracy of magnetic resonance imaging in differentiating between benign and malignant vertebral lesions: role of diffusion-weighted imaging, in-phase/opposed-phase imaging and apparent diffusion coefficient
    Martel Villagrán, J; Bueno Horcajadas, Á; Pérez Fernández, E; Martín Martín, S
  • Diffusion-weighted MR imaging in differentiation between osteoporotic and neoplastic vertebral fractures
    Pozzi, G; Garcia Parra, C; Stradiotti, P; Tien, TV; Luzzati, A; Zerbi, A
  • Vertebrae adjacent to spinal bone lesion are inconsistent reference markers: a magnetic resonance spectroscopic viewpoint
    Rumpel, H; Chan, LL; Chan, LP; Png, MA; Tan, RK; Lim, WE
  • Benign versus metastatic vertebral compression fractures: combined diffusion-weighted MRI and MR spectroscopy aids differentiation
    Rumpel, H; Chong, Y; Porter, DA; Chan, LL
  • Diffusion-weighted MR imaging for differentiation of benign fracture edema and tumor infiltration of the vertebral body
    Spuentrup, E; Buecker, A; Adam, G; Vaals, JJ; Guenther, RW
  • Can unenhanced multiparametric MRI substitute gadolinium-enhanced MRI in the characterization of vertebral marrow infiltrative lesions?
    Zidan, DZ; Elghazaly, HA
  • Role of whole-body diffusion-weighted MRI in detecting bone metastasis
    Vescovo, R; Frauenfelder, G; Giurazza, F
  • Osteoporotic or malignant vertebral fracture? This is the question. What can we do about it?
    Hamimi, A; Kassab, F; Kazkaz, G
  • Acute vertebral compression fracture: differentiation of malignant and benign causes by diffusion weighted magnetic resonance imaging
    Mubarak, F; Akhtar, W
  • Role of diffusion WIs and T2 * GRE pulse sequences in dubious vertebral marrow pathological lesions
    Osman, OM; Fahmy, YR; El-Oraby, AM; El-Basmy, AA; Amin, YE
  • Single shot fast spin echo diffusion-weighted MR imaging of the spine; Is it useful in differentiating malignant metastatic tumor infiltration from benign fracture edema?
    Park, SW; Lee, JH; Ehara, S
  • Diffusion-weighted MR imaging for differentiating acute benign from pathologic compression fractures: a reinvestigation of the usefulness of diffusion-weighted imaging
    Tzeng, YH; Chang, TY; Huang, GS; Lan, GY; Hou, WY; Shen, HJ
  • Use of diffusion-weighted magnetic resonance imaging to differentiate between acute benign and pathological vertebral fractures: prospective study
    Yao, WW; Li, MH; Yang, SX; Zhu, LL
  • Quantitative analysis of the diffusion-weighted steady-state free precession signal in vertebral bone marrow lesions
    Biffar, A; Baur-Melnyk, A; Schmidt, GP; Reiser, MF; Dietrich, O
  • Multiparameter MRI assessment of normal-appearing and diseased vertebral bone marrow
    Biffar, A; Baur-Melnyk, A; Schmidt, GP; Reiser, MF; Dietrich, O
  • Comparison of qualitative and quantitative evaluation of diffusion-weighted MRI and chemical-shift imaging in the differentiation of benign and malignant vertebral body fractures
    Geith, T; Schmidt, G; Biffar, A
  • Role of DWI in characterization of bone tumors
    Geneidi, EASH; Ali, HI; Dola, EF
  • Vertebral body compression fracture: discriminating benign from malignant causes by diffusion-weighted MR imaging and apparent diffusion coefficient value
    Wonglaksanapimon, S; Chawalparit, O; Khumpunnip, S; Tritrakarn, SO; Chiewvit, P; Charnchaowanish, P
  • The value of apparent diffusion coefficient measurements in the differential diagnosis of vertebral bone marrow lesions
    Taskin, G; Incesu, L; Aslan, K
  • Discrimination between benign and malignant in vertebral marrow lesions with diffusion weighted MRI and chemical shift
    Tardos, MY; Louka, AL
  • Differentiation of acute osteoporotic and malignant compression fractures of the spine: use of additive qualitative and quantitative axial diffusion-weighted MR imaging to conventional MR imaging at 3.0 T
    Sung, JK; Jee, WH; Jung, JY
  • Diffusion-weighted magnetic resonance imaging of spinal infection and malignancy
    Pui, MH; Mitha, A; Rae, WI; Corr, P
  • Intravoxel incoherent motion diffusion-weighted magnetic resonance imaging of focal vertebral bone marrow lesions: initial experience of the differentiation of nodular hyperplastic hematopoietic bone marrow from malignant lesions
    Park, S; Kwack, KS; Chung, NS; Hwang, J; Lee, HY; Kim, JH
  • Single-shot echo-planar diffusion-weighted MR imaging at 3T and 1.5T for differentiation of benign vertebral fracture edema and tumor infiltration
    Park, HJ; Lee, SY; Rho, MH
  • Quantitative evaluation of benign and malignant vertebral fractures with diffusion-weighted MRI: what is the optimum combination of b values for ADC-based lesion differentiation with the single-shot turbo spin-echo sequence?
    Geith, T; Schmidt, G; Biffar, A
  • Diagnostic value of apparent diffusion coefficient to differentiate benign from malignant vertebral bone marrow lesions
    Fawzy, F; Tantawy, HI; Ragheb, A; Abo Hashem, S
  • Differentiation of acute osteoporotic from malignant vertebral compression fractures with conventional MRI and diffusion MR imaging
    Abowarda, MH; Abdel-Rahman, HM; Taha, MM
  • Evaluation of benign and malignant vertebral lesions with diffusion weighted magnetic resonance imaging and apparent diffusion coefficient measurements
    Abo Dewan, KAW; Salama, AA; Habashy, HMS; Khalil, AES
  • Diffusion-weighted MRI in the body: applications and challenges in oncology
    Koh, DW; Collins, DJ
  • Diffusion-weighted whole-body imaging with background body signal suppression (DWIBS): features and potential applications in oncology
    Kwee, TC; Takahara, T; Ochiai, R; Nievelstein, RAJ; Luiten, PR
  • Diffusion weighted MR imaging of upper abdominal organs: field strength and intervendor variability of apparent diffusion coefficients
    Donati, OF; Chong, D; Nanz, D
  • Field strength and diffusion encoding technique affect the apparent diffusion coefficient measurements in diffusion-weighted imaging of the abdomen
    Dale, BM; Braithwaite, AC; Boll, DT; Merkle, EM

You’re reading a free preview. Subscribe to read the entire article.

Try 2 weeks free now

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

or browse the journals available

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off

Sign up
for free
Start 14 day
Free Trial