Reactions 1680, p18 - 2 Dec 2017 Invasive salmonellosis caused by Salmonella choleraesuis and recurrent bacteraemia: case report A 52-year-old man developed invasive salmonellosis caused by Salmonella choleraesuis and recurrent bacteraemia during treatment with adalimumab [Humira] and mercaptopurine [6-mercaptopurine]. The man, who had a history of Crohn’s disease, liver cirrhosis and non-alcoholic steatohepatitis, presented in April 2011 with a four-day history of fever, chills and severe headache, which started approximately one week after his return from Dominican Republic where he had travelled for a 10 day vacation. He also had nausea and vomiting. He did not receive any prophylaxis or vaccinations prior to his travel. He was on an injection of adalimumab 40mg weekly and oral mercaptopurine 75mg daily for the previous 2 years for Crohn’s disease, which was diagnosed more than 20 years prior. Physical examination revealed a fever of 103.8°C. Laboratory tests revealed a WBC count of 3,500 /µL and two blood cultures grew Salmonella choleraesuis susceptible to ceftriaxone and ciprofloxacin. The man was treated with ceftriaxone with a good clinical response and his fever resolved within 36 hours. Also, repeat blood cultures two days after antibiotics therapy showed no growth. He was discharged home on a two week course of ciprofloxacin. However, he was readmitted one month later due to similar symptoms as well as recurrent bacteraemia due to the same organism. His adalimumab was temporarily stopped and he was discharged home on a one-month course of ceftriaxone. He did well without any recurrence on six months follow-up. Author comment: "The index patient had multiple immunosuppressing conditions besides being on a biologic agent that increased his risk for invasive disease." "S. choleraesuis causes primary bacteremia . . . especially in the immunosuppressed, older patient" "[Immunosuppression] is the most significant risk factor for invasive salmonellosis due to this organism" "There is an increasing report of invasive salmonellosis cases among patients on [anti-TNF-α agents]" Eke UA, et al. Invasive salmonellosis by the very rare Salmonella choleraesuis in a returning traveler on a tumor necrosis factor-alpha inhibitor. Case Reports in Medicine 2014: 23 Feb 2014. Available from: URL: http:// doi.org/10.1155/2014/934657 - USA 803285243 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680
Reactions Weekly – Springer Journals
Published: Dec 2, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera