Adalimumab/etanercept

Adalimumab/etanercept Reactions 1704, p19 - 2 Jun 2018 Sarcoid-like granulomatosis: case report A 17-year-old boy developed paradoxical sarcoid-like granulomatosis during treatment with etanercept and adalimumab [routes and dosages not stated] for psoriasis. The boy, who had been diagnosed with psoriasis at the age of 3, had received unspecified steroids in the past. He presented with abdominal pain, fatigue and weight loss. He had received etanercept for 2 years followed by adalimumab for the past year before this presentation. An abdominal CT scan showed lymphadenopathy. A positron emission tomography (PET)/CT scan showed hyper-metabolic diffuse lymphadenopathy involving neck, chest, retroperitoneal and mesenteric lymph nodes. An axillary lymph node biopsy demonstrated numerous, epithelioid and non-ceseating coalescing granulomas with multi-nucleated giant-cells. The boy’s treatment with adalimumab was stopped. Eventually, he recovered. Author comment: "This case illustrates the rare, paradoxical adverse effect of sarcoid-like granulomatosis in patients treated with anti-TNFa for chronic inflammatory diseases." Leventaki V, et al. Sarcoid-like granulomatosis in a patient receiving anti- TNFalpha for psoriasis. American Journal of Hematology 93: 722-723, No. 5, May 2018. Available from: URL: http://doi.org/10.1002/ajh.25021 - USA 803322760 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Adalimumab/etanercept

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46662-6
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p19 - 2 Jun 2018 Sarcoid-like granulomatosis: case report A 17-year-old boy developed paradoxical sarcoid-like granulomatosis during treatment with etanercept and adalimumab [routes and dosages not stated] for psoriasis. The boy, who had been diagnosed with psoriasis at the age of 3, had received unspecified steroids in the past. He presented with abdominal pain, fatigue and weight loss. He had received etanercept for 2 years followed by adalimumab for the past year before this presentation. An abdominal CT scan showed lymphadenopathy. A positron emission tomography (PET)/CT scan showed hyper-metabolic diffuse lymphadenopathy involving neck, chest, retroperitoneal and mesenteric lymph nodes. An axillary lymph node biopsy demonstrated numerous, epithelioid and non-ceseating coalescing granulomas with multi-nucleated giant-cells. The boy’s treatment with adalimumab was stopped. Eventually, he recovered. Author comment: "This case illustrates the rare, paradoxical adverse effect of sarcoid-like granulomatosis in patients treated with anti-TNFa for chronic inflammatory diseases." Leventaki V, et al. Sarcoid-like granulomatosis in a patient receiving anti- TNFalpha for psoriasis. American Journal of Hematology 93: 722-723, No. 5, May 2018. Available from: URL: http://doi.org/10.1002/ajh.25021 - USA 803322760 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

References

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