Active cell-matrix coupling regulates cellular force landscapes of cohesive epithelial monolayers

Active cell-matrix coupling regulates cellular force landscapes of cohesive epithelial monolayers Epithelial cells can assemble into cohesive monolayers with rich morphologies on substrates due to competition between elastic, edge, and interfacial effects. Here we present a molecularly based thermodynamic model, integrating monolayer and substrate elasticity, and force-mediated focal adhesion formation, to elucidate the active biochemical regulation over the cellular force landscapes in cohesive epithelial monolayers, corroborated by microscopy and immunofluorescence studies. The predicted extracellular traction and intercellular tension are both monolayer size and substrate stiffness dependent, suggestive of cross-talks between intercellular and extracellular activities. Our model sets a firm ground toward a versatile computational framework to uncover the molecular origins of morphogenesis and disease in multicellular epithelia. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png npj Computational Materials Springer Journals

Active cell-matrix coupling regulates cellular force landscapes of cohesive epithelial monolayers

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Publisher
Nature Publishing Group UK
Copyright
Copyright © 2018 by The Author(s)
Subject
Materials Science; Materials Science, general; Characterization and Evaluation of Materials; Mathematical and Computational Engineering; Theoretical, Mathematical and Computational Physics; Computational Intelligence; Mathematical Modeling and Industrial Mathematics
eISSN
2057-3960
D.O.I.
10.1038/s41524-018-0069-8
Publisher site
See Article on Publisher Site

Abstract

Epithelial cells can assemble into cohesive monolayers with rich morphologies on substrates due to competition between elastic, edge, and interfacial effects. Here we present a molecularly based thermodynamic model, integrating monolayer and substrate elasticity, and force-mediated focal adhesion formation, to elucidate the active biochemical regulation over the cellular force landscapes in cohesive epithelial monolayers, corroborated by microscopy and immunofluorescence studies. The predicted extracellular traction and intercellular tension are both monolayer size and substrate stiffness dependent, suggestive of cross-talks between intercellular and extracellular activities. Our model sets a firm ground toward a versatile computational framework to uncover the molecular origins of morphogenesis and disease in multicellular epithelia.

Journal

npj Computational MaterialsSpringer Journals

Published: Mar 14, 2018

References

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