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P. Galen, G. Stiles, George Michaels, K. Jacobson (1992)
Adenosine A1 and A2 receptors: Structure–function relationshipsMedicinal Research Reviews, 12
An-Hu Li, Stefano Moro, Nancy Forsyth, N. Melman, X. Ji, Kenneth Jacobson (1999)
Synthesis, CoMFA analysis, and receptor docking of 3,5-diacyl-2, 4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists.Journal of medicinal chemistry, 42 4
F. Atia, W. Zeiske, W. Driessche (1999)
Secretory apical Cl– channels in A6 cells: possible control by cell Ca2+ and cAMPPflügers Archiv, 438
(1994)
Adenosine A 3 receptor stimulation and cerebral ischemia
K. Jacobson, H. Kim, S. Siddiqi, M. Olah, G. Stiles, D. Lubitz (1995)
A3-adenosine receptors: design of selective ligands and therapeutic prospects.Drugs of the future, 20 7
(1999)
Use of the triazolotriazine
Hydraulic Excavator (2019)
The New GenerationThe Women's Liberation Movement in Russia
D. Weaver, S. Reppert (1992)
Adenosine receptor gene expression in rat kidney.The American journal of physiology, 263 6 Pt 2
M. Yanase, J. Handler (1986)
Adenosine 3',5'-cyclic monophosphate stimulates chloride secretion in A6 epithelia.The American journal of physiology, 251 5 Pt 1
(1995)
2+ influx mechanism.J
V. Casavola, L. Guerra, S. Reshkin, K. Jacobson, F. Verrey, H. Murer (1996)
Effect of Adenosine on Na+ and Cl− Currents in A6 Monolayers. Receptor Localization and Messenger InvolvementThe Journal of Membrane Biology, 151
S. Pandol, M. Schoeffield, Claus Fimmel, S. Muallem (1987)
The agonist-sensitive calcium pool in the pancreatic acinar cell. Activation of plasma membrane Ca2+ influx mechanism.The Journal of biological chemistry, 262 35
M. Ui, T. Katada, T. Murayama, H. Kurose, M. Yajima, M. Tamura, T. Nakamura, K. Nogimori (1984)
Islet-activating protein, pertussis toxin: a specific uncoupler of receptor-mediated inhibition of adenylate cyclase.Advances in cyclic nucleotide and protein phosphorylation research, 17
Ji-long Jiang, A. Rhee, N. Melman, X. Ji, K. Jacobson (1996)
6-phenyl-1,4-dihydropyridine derivatives as potent and selective A3 adenosine receptor antagonists.Journal of medicinal chemistry, 39 23
(1997)
Regulation of chloride transport by IBMX in renal A6 epithelium.Pfluegers Arch.434:227–233
Joel Linden, H. Taylor, Anna Robeva, Amy Tucker, Jörg Stehle, S. Rivkees, J. Fink, S. Reppert (1993)
Molecular cloning and functional expression of a sheep A3 adenosine receptor with widespread tissue distribution.Molecular pharmacology, 44 3
V. Ramkumar, G. Stiles, M. Beaven, H. Ali (1993)
The A3 adenosine receptor is the unique adenosine receptor which facilitates release of allergic mediators in mast cells.The Journal of biological chemistry, 268 23
Yutaka Kohno, Yoshitatsu Sei, Masahiro Koshiba, Hea Kim, Kenneth Jacobson (1996)
Induction of apoptosis in HL-60 human promyelocytic leukemia cells by adenosine A(3) receptor agonists.Biochemical and biophysical research communications, 219 3
(1998)
Struc - ture activity relationships and molecular modeling of 3 , 5 - diacyl - 2 , 4 - dialkylpyridine derivatives as selective A 3 adenosine receptor antagonists
(1997)
Regulation of chloride transport by IBMX in renal A 6 epithelium
M. Abbracchio, Roberta Brambilla, S. Ceruti, Hea Kim, D. Lubitz, Kenneth Jacobson, Flaminio Cattabeni (1995)
G protein-dependent activation of phospholipase C by adenosine A3 receptors in rat brain.Molecular pharmacology, 48 6
C. Salvatore, M. Jacobson, H. Taylor, J. Linden, Robert Johnson (1993)
Molecular Cloning and Characterization of the Human A_3 Adenosine ReceptorProceedings of the National Academy of Sciences of the United States of America
Wei-Jen Tang, John Krupinski, A. Gilman (1991)
Expression and characterization of calmodulin-activated (type I) adenylylcyclase.The Journal of biological chemistry, 266 13
V. Casavola, L. Guerra, S. Reshkin, K. Jacobson, H. Murer (1997)
Polarization of adenosine effects on intracellular pH in A6 renal epithelial cells.Molecular pharmacology, 51 3
(1999)
A3 adenosine receptors
G. Friedlander, C. Amiel (1995)
Extracellular nucleotides as modulators of renal tubular transport.Kidney international, 47 6
(1999)
Synthesis, CoMFA analysis, and receptor docking of 3,5diacyl-2,4-dialkylpyridine derivatives as selective A
J. Hoenderop, A. Hartog, P. Willems, R. Bindels (1998)
Adenosine-stimulated Ca2+reabsorption is mediated by apical A1 receptors in rabbit cortical collecting system.American journal of physiology. Renal physiology, 274 4
C. Mitchell, K. Peterson‐Yantorno, D. Carré, A. McGlinn, M. Coca‐Prados, R. Stone, M. Civan (1999)
A3 adenosine receptors regulate Cl-channels of nonpigmented ciliary epithelial cells.American journal of physiology. Cell physiology, 276 3
E. Siga, A. Champigneulle, M. Imbert-Teboul (1994)
cAMP-dependent effects of vasopressin and calcitonin on cytosolic calcium in rat CCD.The American journal of physiology, 267 3 Pt 2
M. Lang, A. Preston, J. Handler, J. Forrest (1985)
Adenosine stimulates sodium transport in kidney A6 epithelia in culture.The American journal of physiology, 249 3 Pt 1
D. McCoy, S. Bhattacharya, B. Olson, D. Levier, Lois Arend, William Spielman (1993)
The renal adenosine system: structure, function, and regulation.Seminars in nephrology, 13 1
W. Moolenaar (1990)
Na + /H + Exchange
E. Schwiebert, K. Karlson, P. Friedman, P. Dietl, W. Spielman, B. Stanton (1992)
Adenosine regulates a chloride channel via protein kinase C and a G protein in a rabbit cortical collecting duct cell line.The Journal of clinical investigation, 89 3
(1996)
cells: polarity and vasopressin regulation
(1999)
Secretory apical Cl
C. Zocchi, E. Ongini, A. Conti, A. Monopoli, A. Negretti, P. Baraldi, S. Dionisotti (1996)
The non-xanthine heterocyclic compound SCH 58261 is a new potent and selective A2a adenosine receptor antagonist.The Journal of pharmacology and experimental therapeutics, 276 2
An-Hu Li, S. Moro, N. Melman, X. Ji, K. Jacobson (1998)
Structure-activity relationships and molecular modeling of 3, 5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists.Journal of medicinal chemistry, 41 17
(1995)
Review: Neurotransmitter receptors VII
(1993)
Molecular cloning and characterization of the human A
(1993)
Molecular cloning and functional expression of a sheep A
M. Chalfant, B. Coupaye-Gerard, T. Kleyman (1993)
Distinct regulation of Na+ reabsorption and Cl- secretion by arginine vasopressin in the amphibian cell line A6.The American journal of physiology, 264 6 Pt 1
(1998)
A 3 adenosine receptors : Novel ligands and paradoxical effects
T. Chijiwa, A. Mishima, M. Hagiwara, M. Sano, Kyozo Hayashi, Tsutomu Inoue, Naito Kenji, T. Toshioka, Hiroyoshi Hidaka (1990)
Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells.The Journal of biological chemistry, 265 9
(1990)
Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMPdependent protein kinase
K. Fleming, D. Mogul (1997)
Adenosine A3 Receptors Potentiate Hippocampal Calcium Current by a PKA-dependent/PKC-independent PathwayNeuropharmacology, 36
Y. Marunaka, D. Eaton (1990)
Chloride channels in the apical membrane of a distal nephron A6 cell line.The American journal of physiology, 258 2 Pt 1
A. Yatani, A. Brown (1989)
Rapid beta-adrenergic modulation of cardiac calcium channel currents by a fast G protein pathway.Science, 245 4913
L. Arend, W. Sonnenburg, W. Smith, W. Spielman (1987)
A1 and A2 adenosine receptors in rabbit cortical collecting tubule cells. Modulation of hormone-stimulated cAMP.The Journal of clinical investigation, 79 3
Jennifer Strickler, Kenneth Jacobson, Bruce Liang (1996)
Direct preconditioning of cultured chick ventricular myocytes. Novel functions of cardiac adenosine A2a and A3 receptors.The Journal of clinical investigation, 98 8
Q. Zhou, Chuanyu Li, M. Olah, Robert Johnson, G. Stiles, O. Civelli (1992)
Molecular cloning and characterization of an adenosine receptor: the A3 adenosine receptor.Proceedings of the National Academy of Sciences of the United States of America, 89
J. Hayslett, L. Macala, J. Smallwood, L. Kalghatgi, Jose Gassala-Herraiz, C. Isales (1995)
Vasopressin-stimulated Electrogenic Sodium Transport in A6 Cells Is Linked to a Ca2+-mobilizing Signal Mechanism (*)The Journal of Biological Chemistry, 270
D. Levier, D. McCoy, William Spielman (1992)
Functional localization of adenosine receptor-mediated pathways in the LLC-PK1 renal cell line.The American journal of physiology, 263 4 Pt 1
M. Breyer (1991)
Feedback inhibition of cyclic adenosine monophosphate-stimulated Na+ transport in the rabbit cortical collecting duct via Na(+)-dependent basolateral Ca++ entry.The Journal of clinical investigation, 88 5
X. Ji, K. Jacobson (1999)
Use of the triazolotriazine [3H]ZM 241385 as a radioligand at recombinant human A2B adenosine receptors.Drug design and discovery, 16 3
Bertil, B., Fredholm, Maria, P., Abbracchio, Geoffrey, Burnstock, John, W., Daly, T., Kendall (2005)
Nomenclature and Classification of Purinoceptors*
D. Light, E. Schwiebert, G. Fejes-Tóth, A. Náray-Fejes-Tóth, K. Karlson, F. McCann, B. Stanton (1990)
Chloride channels in the apical membrane of cortical collecting duct cells.The American journal of physiology, 258 2 Pt 2
G. Grynkiewicz, M. Poenie, Roger TsienB (1985)
A new generation of Ca2+ indicators with greatly improved fluorescence properties.The Journal of biological chemistry, 260 6
(1994)
cAMPdependent effects of vasopressin and calcitonin on cytosolic calcium in rat
D. Lubitz, Rick Lin, Piotr Popik, M. Carter, Kenneth Jacobson (1994)
Adenosine A3 receptor stimulation and cerebral ischemia.European journal of pharmacology, 263 1-2
J. Daly, K. Jacobson (1995)
Adenosine Receptors:Selective Agonists and Antagonists
(1997)
Expression of the cysic fibrosis phenotype in a renal amphibian epithelial cell line
(1995)
The in vitro pharmacology of ZM 241385 , a novel non xanthine A 2 A selective adenosine antagonist
M Otah, G Stiles (1995)
Adenosine receptors.Neuropharmacology, 34 7
M. Kreisberg, E. Silldorff, T. Pallone (1997)
Localization of adenosine-receptor subtype mRNA in rat outer medullary descending vasa recta by RT-PCR.The American journal of physiology, 272 3 Pt 2
We have previously demonstrated that in A6 renal epithelial cells, a commonly used model of the mammalian distal section of the nephron, adenosine A1 and A2A receptor activation modulates sodium and chloride transport and intracellular pH (Casavola et al., 1997). Here we show that apical addition of the A3 receptor-selective agonist, 2-chloro-N6-(3-iodobenzyl)-adenosine-5′-methyluronamide (Cl-IB-MECA) stimulated a chloride secretion that was mediated by calcium- and cAMP-regulated channels. Moreover, in single cell measurements using the fluorescent dye Fura 2-AM, Cl-IB-MECA caused an increase in Ca2+ influx. The agonist-induced rise in [Ca2+] i was significantly inhibited by the selective adenosine A3 receptor antagonists, 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate (MRS 1523) and 3-ethyl 5-benzyl 2-methyl-6-phenyl-4-phenylethynyl-1,4-(±)-dihydropyridine-3,5-dicarboxylate (MRS 1191) but not by antagonists of either A1 or A2 receptors supporting the hypothesis that Cl-IB-MECA increases [Ca2+] i by interacting exclusively with A3 receptors. Cl-IB-MECA-elicited Ca2+ entry was not significantly inhibited by pertussis toxin pretreatment while being stimulated by cholera toxin preincubation or by raising cellular cAMP levels with forskolin or rolipram. Preincubation with the protein kinase A inhibitor, H89, blunted the Cl-IB-MECA-elicited [Ca2+] i response. Moreover, Cl-IB-MECA elicited an increase in cAMP production that was inhibited only by an A3 receptor antagonist. Altogether, these data suggest that in A6 cells a G s /protein kinase A pathway is involved in the A3 receptor-dependent increase in calcium entry.
The Journal of Membrane Biology – Springer Journals
Published: Nov 15, 2000
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