Acitretin

Acitretin Reactions 1704, p15 - 2 Jun 2018 Retinoic acid syndrome: case report A 67-year-old man developed retinoic acid syndrome during treatment with acetretin for psoriasis. The man, who had been initiated on oral acetretin 35mg for psoriasis 6 months prior, presented with fever, cough, haemoptysis and an acute onset of dyspnoea, which had rapidly progressed over the previous 4 days. Physical examination revealed the following: temperature 101F, oxygen saturation 60% on room air, BP 120/80mm Hg with tachypnoea and tachycardia. Dispersed ronchi and bilateral coarse crepetations were heard upon chest auscultation. Laboratory analyses revealed leukocytosis. Serum creatinine was found to be 1.3 mg/dL. Arterial blood gas analysis indicated hypoxia. A chest x-ray upon hospitalisation showed dense consolidation involving both his lungs. The man was commenced on broad spectrum antibiotics on a preliminary diagnosis of community-acquired pneumonia. However, his condition deteriorated over the following 24 hours. He experienced an aggravation of symptoms, haematuria and new onset hypotension. Ground glass opacities, bilateral interstitial and alveolar infiltrates with consolidation were observed in a chest CT scan. Furthermore, his CRP and ECG were normal; blood and sputum cultures, ANA and ANCA were negative. A retrospective review of his therapeutic regimen facilitated the diagnosis of acitretin- induced retinoic acid syndrome. Acitretin was discontinued, and he was commenced on methylprednisolone. A marked improvement was noted in his condition 48 hours after steroid administration. With a reduction in respiratory rate, his oxygen consumption reduced; oxygen saturation being 94% on room air. His BP normalised and crepetations resolved. His serum creatinine was 0.9 mg/dL and leukocyte count had also improved at follow-up. The opacities observed on the chest x- ray were less dense. The dose of methylprednisolone was tapered over 2 weeks; a chest x-ray 9 days after initiating corrective therapy revealed that the opacities had completely resolved. Author comment: "Here we report a case of elderly male with psoriasis presenting with acitretin induced retinoic acid syndrome." Metage C, et al. Retinoic acid syndrome in a elderly male with psoriasis- A case report. Respiratory Medicine Case Reports 24: 81-83, Jan 2018. Available from: URL: http://doi.org/10.1016/j.rmcr.2018.04.007 - India 803322911 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Acitretin

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46658-7
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p15 - 2 Jun 2018 Retinoic acid syndrome: case report A 67-year-old man developed retinoic acid syndrome during treatment with acetretin for psoriasis. The man, who had been initiated on oral acetretin 35mg for psoriasis 6 months prior, presented with fever, cough, haemoptysis and an acute onset of dyspnoea, which had rapidly progressed over the previous 4 days. Physical examination revealed the following: temperature 101F, oxygen saturation 60% on room air, BP 120/80mm Hg with tachypnoea and tachycardia. Dispersed ronchi and bilateral coarse crepetations were heard upon chest auscultation. Laboratory analyses revealed leukocytosis. Serum creatinine was found to be 1.3 mg/dL. Arterial blood gas analysis indicated hypoxia. A chest x-ray upon hospitalisation showed dense consolidation involving both his lungs. The man was commenced on broad spectrum antibiotics on a preliminary diagnosis of community-acquired pneumonia. However, his condition deteriorated over the following 24 hours. He experienced an aggravation of symptoms, haematuria and new onset hypotension. Ground glass opacities, bilateral interstitial and alveolar infiltrates with consolidation were observed in a chest CT scan. Furthermore, his CRP and ECG were normal; blood and sputum cultures, ANA and ANCA were negative. A retrospective review of his therapeutic regimen facilitated the diagnosis of acitretin- induced retinoic acid syndrome. Acitretin was discontinued, and he was commenced on methylprednisolone. A marked improvement was noted in his condition 48 hours after steroid administration. With a reduction in respiratory rate, his oxygen consumption reduced; oxygen saturation being 94% on room air. His BP normalised and crepetations resolved. His serum creatinine was 0.9 mg/dL and leukocyte count had also improved at follow-up. The opacities observed on the chest x- ray were less dense. The dose of methylprednisolone was tapered over 2 weeks; a chest x-ray 9 days after initiating corrective therapy revealed that the opacities had completely resolved. Author comment: "Here we report a case of elderly male with psoriasis presenting with acitretin induced retinoic acid syndrome." Metage C, et al. Retinoic acid syndrome in a elderly male with psoriasis- A case report. Respiratory Medicine Case Reports 24: 81-83, Jan 2018. Available from: URL: http://doi.org/10.1016/j.rmcr.2018.04.007 - India 803322911 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

References

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