Aciclovir Reactions 1680, p14 - 2 Dec 2017 Transient renal dysfunction: case report A 12-year-old boy developed transient renal dysfunction during treatment with aciclovir [acyclovir]. The boy, who developed small papules and blisters on the left side of his face, severe headache and hyperaemia of the left bulbar conjunctiva, was started on treatment with IV acyclovir 31 mg/kg/day. The symptoms did not resolve after 4 days of aciclovir treatment and he vomited repeatedly. From a PCR, he was eventually diagnosed with Herpes zoster meningitis and his aciclovir dose was increased to 53 mg/kg/day. Subsequently, his symptoms improved. Five days later, his serum creatinine increased from 0.57 mg/dL to 0.88 mg/dL. The dose of aciclovir was reduced back to 31 mg/kg/day and the serum creatinine improved to 0.55 mg/dL. The changes in serum creatinine were suggestive of transient renal dysfunction. Author comment: "We should consider increasing the [aciclovir] dosage to the maximum dose, while monitoring for drug induced renal disorder, even in healthy children." Itoh N, et al. Herpes zoster meningitis in immunocompetent children: Two case reports and a literature review. Pediatrics International 59: 1116-1118, No. 10, Oct 2017. Available from: URL: - Japan 803284324 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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