Aciclovir Reactions 1664, p18 - 12 Aug 2017 Seizures: case report In a retrospective study, an infant [age and sex not stated] was identified, who developed seizures following off-label high dose treatment with aciclovir [acyclovir]. The infant with neonatal herpes simplex virus (HSV) infection localized to skin, eyes or mucous membranes, was started on treatment with high dose (off-label for infants) aciclovir [exact dosage and route not stated], developed seizures [duration of treatment to reaction onset and outcome not stated]. Author comment: "Five of the 8 infants who had a seizure had virologic confirmation of HSV: 2 had CNS disease, 2 had disseminated disease and 1 had [skin, eyes or mucous membranes] disease." "We identified 89 infants during the study period with 1658 days of acyclovir exposure. Almost all received high-dose acyclovir therapy (79/89, 89%). The most common clinical AEs were hypotension and seizure, both occurring in 9% of infants." Ericson JE, et al. Safety of High-dose Acyclovir in Infants With Suspected and Confirmed Neonatal Herpes Simplex Virus Infections. Pediatric Infectious Disease Journal 36: 369-373, No. 4, Apr 2017. Available from: URL: http:// - USA 803262131 0114-9954/17/1664-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 12 Aug 2017 No. 1664 Reactions Weekly Springer Journals


Reactions Weekly , Volume 1664 (1) – Aug 12, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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