Reactions 1680, p13 - 2 Dec 2017 Nephropathy: case report A 35-year-old man developed nephropathy after receiving treatment with aciclovir [acyclovir]. The man was hospitalised with fever refractory to antipyretics medications. He was diagnosed with viral encephalitis. He started receiving IV aciclovir 750 mg/8 hours. Three days later, his creatinine level abruptly increased to 6.9 mg/dL, accompanied with reduction in his consciousness. His aciclovir dose was adjusted to 750 mg/24 hours, after which he regained consciousness and his renal function tests normalised. Author comment: "The present case showed that high- dose intravenous acyclovir might induce nephropathy due to direct renal tubular toxicity, acute interstitial nephritis, and crystal nephropathy." Aziz MAE, et al. Acyclovir-induced nephropathy in an encephalitis patient: A case report and review of literature. CNS Spectrums 22: 88 abstr. 146, No. 1, Feb 2017. Available from: URL: http://doi.org/10.1017/S1092852916000900 [abstract] - Egypt 803284843 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680
Reactions Weekly – Springer Journals
Published: Dec 2, 2017
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