Acetylcysteine Reactions 1664, p17 - 12 Aug 2017 Clinical deterioration of ethylmalonic encephalopathy: case report A 29-year-old woman experienced clinical deterioration of ethylmalonic encephalopathy during treatment with acetylcysteine [N-acetylcysteine]. She had a history of ethylmalonic encephalopathy and was started on acetylcysteine [dose and route not stated]. However, she experienced clinical worsening of ethylmalonic encephalopathy. Therefore, after eight months, the treatment with acetylcysteine was stopped and her condition was fully reversed. Author comment: "The treatment trial with [acetylcysteine] was aborted after 8 months due to clinical deterioration fully reversible after ending [acetylcysteine] intake." "This case expands the known phenotype and prompts caution regarding [acetylcysteine] therapy in atypical ethylmalonic encephalopathy." Neuhofer C, et al. A new phenotype of ethylmalonic encephalopathy. European Journal of Neurology 24 (Suppl. 1): 505 abstr. PR1105, Jul 2017. Available from: URL: [abstract] - Germany 803263365 0114-9954/17/1664-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 12 Aug 2017 No. 1664 Reactions Weekly Springer Journals


Reactions Weekly , Volume 1664 (1) – Aug 12, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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