Acetazolamide Reactions 1664, p16 - 12 Aug 2017 Non-cardiogenic pulmonary oedema: case report A 61-year-old man developed non-cardiogenic pulmonary oedema during treatment with acetazolamide. The man was admitted to the ICU because of severe blunt chest wall trauma due to a motor vehicle accident. He was on prolonged ventilator support due to his chest wall instability and cardiomyopathy. On day 17 of hospitalisation, to correct metabolic alkalosis and increase urine output, he was administered IV acetazolamide 500mg. He developed tachycardia, hypertension and hypoxaemia one hour following the injection of acetazolamide. Chest auscultation revealed wheezing sounds, and a pinkish foamy secretion was removed through his tracheal tube. He exhibited choking-like signs, and his ventilator monitor revealed a very high airway pressure and significantly decreased tidal volume, following which his ventilation was changed to manual. A bilateral butterfly shadow was revealed by chest radiography. An acute pulmonary oedema due to acute exacerbation of congestive heart failure was suspected. The man received treatment for respiratory failure with diuretics, nitric acid and a β2 stimulant to reduce the airway pressure. After approximately eight hours, the event resolved. The man was administered the same dose of acetazolamide five days after the previous episode for the same reason. He had an abrupt incident of respiratory failure, which was the same as the first episode. A very poor lung compliance and slight increase in airway resistance was recorded on the ventilator, which indicated that the high airway pressure was due to pulmonary parenchymal oedema. An ECG showed a hypercontractile left ventricle without signs of fluid overload. He was administered β blocker to suppress symptoms of hypertension and tachycardia, following which the second episode resolved spontaneously. The cardiac indexes measured via radial arterial catheter indicated that his cardiac output had increased during the episodes. Hence, a diagnosis of pulmonary oedema caused by acetazolamide was made. Author comment: "[We] encountered rare and potentially fatal episodes of pulmonary [oedema] that was provoked by treatment with acetazolamide." Ono Y, et al. A case of non-cardiogenic pulmonary edema provoked by intravenous acetazolamide. Acute Medicine and Surgery 4: 349-352, No. 3, Jul 2017. Available from: URL: - Japan 803263013 0114-9954/17/1664-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 12 Aug 2017 No. 1664 Reactions Weekly Springer Journals


Reactions Weekly , Volume 1664 (1) – Aug 12, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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