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H. Maharaj, D. Maharaj, S. Daya (2006)
Acetylsalicylic acid and acetaminophen protect against MPP+-induced mitochondrial damage and superoxide anion generation.Life sciences, 78 21
O. Lowry, N. Rosebrough, A. Farr, R. Randall (1951)
Protein measurement with the Folin phenol reagent.The Journal of biological chemistry, 193 1
Jun-ichi Suzuki, Norio Katoh (1990)
A simple and cheap methods for measuring serum vitamin A in cattle using only a spectrophotometer.Nihon juigaku zasshi. The Japanese journal of veterinary science, 52 6
I. Desai (1984)
Vitamin E analysis methods for animal tissues.Methods in enzymology, 105
R. Lawrence, R. Lawrence, R. Burk, R. Burk (1976)
Glutathione peroxidase activity in selenium-deficient rat liver.Biochemical and biophysical research communications, 71 4
X. Lei, Jian Zhu, J. Mcclung, M. Aregullin, C. Roneker (2006)
Mice deficient in Cu,Zn-superoxide dismutase are resistant to acetaminophen toxicity.The Biochemical journal, 399 3
M. Duchen (2000)
Mitochondria and calcium: from cell signalling to cell deathThe Journal of Physiology, 529
L. James, P. Mayeux, J. Hinson (2003)
Acetaminophen-induced hepatotoxicity.Drug metabolism and disposition: the biological fate of chemicals, 31 12
S. Yee, M. Bourdi, M. Masson, L. Pohl (2007)
Hepatoprotective role of endogenous interleukin-13 in a murine model of acetaminophen-induced liver disease.Chemical research in toxicology, 20 5
Norell Hadzimichalis, Sunanda Baliga, R. Golfetti, K. Jaques, B. Firestein, G. Merrill (2007)
Acetaminophen-mediated cardioprotection via inhibition of the mitochondrial permeability transition pore-induced apoptotic pathway.American journal of physiology. Heart and circulatory physiology, 293 6
I. Eren, M. Nazıroğlu, Arif Demirdaş (2007)
Protective Effects of Lamotrigine, Aripiprazole and Escitalopram on Depression-induced Oxidative Stress in Rat BrainNeurochemical Research, 32
OH Lowry (1951)
265J Biol Chem, 193
İ. Özmen, M. Nazıroğlu, H. Alici, F. Şahin, M. Cengiz, I. Eren (2006)
Spinal Morphine Administration Reduces the Fatty Acid Contents in Spinal Cord and Brain by Increasing Oxidative StressNeurochemical Research, 32
B. Halliwell (2006)
Oxidative stress and neurodegeneration: where are we now?Journal of Neurochemistry, 97
I Özmen, M Nazıroğlu, HA Alicı, F Sahin, M Cengiz, İ Eren (2007)
Spinal morphine administration reduces the fatty acid contents in spinal cord and brain in rabbits due to oxidative stressNeurochem Res, 32
Hayato Nakagawa, S. Maeda, Yohko Hikiba, T. Ohmae, W. Shibata, Ayako Yanai, K. Sakamoto, K. Ogura, T. Noguchi, M. Karin, H. Ichijo, M. Omata (2008)
Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation.Gastroenterology, 135 4
Debjani Tripathy, P. Grammas (2009)
Acetaminophen protects brain endothelial cells against oxidative stress.Microvascular research, 77 3
V. Niggli, E. Adunyah, J. Penniston, E. Carafoli (1981)
Purified (Ca2+-Mg2+)-ATPase of the erythrocyte membrane. Reconstitution and effect of calmodulin and phospholipids.The Journal of biological chemistry, 256 1
Manisha Patel (2004)
Mitochondrial dysfunction and oxidative stress: cause and consequence of epileptic seizures.Free radical biology & medicine, 37 12
Zheng-bing Lü, Qian Li, Bo-ping Ye, Shan Bian, Ying Wang, Q. Ruan, Wu-tong Wu (2004)
[Protective effects of shark hepatic stimulator substance against acute hepatic injury induced by acetaminophen in mice].Yao xue xue bao = Acta pharmaceutica Sinica, 39 1
C. Nencini, G. Giorgi, Lucia Micheli (2007)
Protective effect of silymarin on oxidative stress in rat brain.Phytomedicine : international journal of phytotherapy and phytopharmacology, 14 2-3
Antonio González, J. Pariente, G. Salido (2007)
Ethanol stimulates ROS generation by mitochondria through Ca2+ mobilization and increases GFAP content in rat hippocampal astrocytesBrain Research, 1178
ZB Lu (2004)
17Acta Pharmacol Sin, 39
ZB Lu, Q Li, BP Ye, S Bian, Y Wang, QP Ruan, WT Wu (2004)
Protective effects of shark hepatic stimulator substance against acute hepatic injury induced by acetaminophen in miceActa Pharmacol Sin, 39
M. Nazıroğlu (2009)
Role of Selenium on Calcium Signaling and Oxidative Stress-induced Molecular Pathways in EpilepsyNeurochemical Research, 34
S. Colegrove, M. Albrecht, D. Friel (2000)
Dissection of Mitochondrial Ca2+ Uptake and Release Fluxes in Situ after Depolarization-Evoked [Ca2+]i Elevations in Sympathetic NeuronsThe Journal of General Physiology, 115
M. Olaleye, B.T. Rocha (2008)
Acetaminophen-induced liver damage in mice: effects of some medicinal plants on the oxidative defense system.Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 59 5
Z. Placer, Linda Cushman, B. Johnson (1966)
Estimation of product of lipid peroxidation (malonyl dialdehyde) in biochemical systems.Analytical biochemistry, 16 2
M. Nazıroğlu, S. Kutluhan, A. Uğuz, Ö. Çelik, R. Bal, P. Butterworth (2009)
Topiramate and Vitamin E Modulate the Electroencephalographic Records, Brain Microsomal and Blood Antioxidant Redox System in Pentylentetrazol-Induced Seizure of RatsJournal of Membrane Biology, 229
M. Nazıroğlu (2007)
New Molecular Mechanisms on the Activation of TRPM2 Channels by Oxidative Stress and ADP-RiboseNeurochemical Research, 32
Yolanda Gutiérrez-Martín, F. Martin-Romero, F. Henao, C. Gutiérrez-Merino (2005)
Alteration of cytosolic free calcium homeostasis by SIN‐1: high sensitivity of L‐type Ca2+ channels to extracellular oxidative/nitrosative stress in cerebellar granule cellsJournal of Neurochemistry, 92
K. Dyke, Meir Sacks, Naureen Qazi (1998)
A new screening method to detect water-soluble antioxidants: acetaminophen (Tylenol) and other phenols react as antioxidants and destroy peroxynitrite-based luminol-dependent chemiluminescence.Journal of bioluminescence and chemiluminescence, 13 6
D Tripathy, P Grammas (2009)
Acetaminophen inhibits neuronal inflammation and protects neurons from oxidative stressJ Neuroinflamm, 6
K. Jaques-Robinson, R. Golfetti, Sunanda Baliga, Norell Hadzimichalis, G. Merrill (2008)
Acetaminophen Is Cardioprotective Against H2O2-Induced Injury In VivoExperimental Biology and Medicine, 233
S. Yatin, S. Yatin, S. Varadarajan, D. Butterfield (2000)
Vitamin E Prevents Alzheimer's Amyloid beta-Peptide (1-42)-Induced Neuronal Protein Oxidation and Reactive Oxygen Species Production.Journal of Alzheimer's disease : JAD, 2 2
P. Whanger (2001)
Selenium and the Brain: A ReviewNutritional Neuroscience, 4
NM Hadzimichalis (2007)
H3348Am J Physiol, 293
J Suzuki, N Katoh (1990)
A simple and cheap method for measuring vitamin A in cattle using only a spectrophotometerJpn J Vet Sci, 52
J. Sedlák, R. Lindsay (1968)
Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent.Analytical biochemistry, 25 1
H. Maharaj, D. Maharaj, Karruppagounder Saravanan, K. Mohanakumar, S. Daya (2004)
Aspirin Curtails the Acetaminophen-Induced Rise in Brain Norepinephrine LevelsMetabolic Brain Disease, 19
M. Bisaglia, V. Venezia, Patrizia Piccioli, S. Stanzione, C. Porcile, C. Russo, F. Mancini, C. Milanese, Gennaro Schettini (2002)
Acetaminophen protects hippocampal neurons and PC12 cultures from amyloid β-peptides induced oxidative stress and reduces NF-κB activationNeurochemistry International, 41
SL Colegrove, MA Albrecht, DD Friel (2000)
Dissection of mitochondrial Ca2+ uptake and release fluxes in situ after depolarization-evoked [Ca2+] i elevations in sympathetic neuronsJ Gen Physiol, 115
M Nazıroğlu (2007)
239
ZA Placer, L Cushman, BC Johnson (1966)
Estimation of products of lipid peroxidation (malonyl dialdehyde) in biological fluidsAnal Biochem, 16
X. Li, S. Xia, Y. Lv, P. He, J. Han, M. Wu (2004)
Conjugation metabolism of acetaminophen and bilirubin in extrahepatic tissues of rats.Life sciences, 74 10
A. Zaidi, D. Fernandes, Jennifer Bean, M. Michaelis (2009)
Effects of paraquat-induced oxidative stress on the neuronal plasma membrane Ca(2+)-ATPase.Free radical biology & medicine, 47 10
Bilgehan Pekiner, N. Evcimen, S. Nebioğlu (2005)
Diabetes‐induced decrease in rat brain microsomal Ca2+‐ATPase activityCell Biochemistry and Function, 23
M Nazıroğlu (2007)
Reactive oxygen species and diseases
S. Schildknecht, A. Daiber, S. Ghisla, R. Cohen, M. Bachschmid (2008)
Acetaminophen inhibits prostanoid synthesis by scavenging the PGHS‐activator peroxynitriteThe FASEB Journal, 22
Acetaminophen, an analgesic and antipyretic drug, rescues neuronal cells from mitochondrial redox impairment and reactive oxygen species (ROS). Excessive administration of acetaminophen above the recommended daily dose range has some negative effects on the brain. We investigated the effects of different doses of acetaminophen on Ca2+-ATPase and the antioxidant redox system in rats. Seventy rats were randomly divided into seven equal groups. The first was used for the control. One dose of 5, 10, 20, 100, 200, and 500 mg/kg acetaminophen was intraperitoneally administered to rats constituting the second, third, fourth, fifth, sixth, and seventh groups, respectively. After 24 h, brain cortical samples were taken and brain microsomal samples were obtained by ultracentrifugation. Brain and microsomal lipid peroxidation (LP) and brain calcium levels in the sixth and seventh groups were increased compared to control. LP levels in the second, third, and forth groups; brain vitamin E levels; brain and microsomal glutathione peroxidase (GSH-Px); and Ca2+-ATPase activity in the sixth and seventh groups were lower than in control, although brain vitamin E concentrations in the second, third, fourth, and fifth groups and microsomal GSH-Px activity in the third and fourth groups were higher than in control. Brain cortical β-carotene and vitamin A concentrations did not differ in the seven groups. In conclusion, 5–100 mg/kg acetaminophen seems to have protective effects on oxidative stress-induced brain toxicity by inhibiting free radicals and supporting the antioxidant redox system.
The Journal of Membrane Biology – Springer Journals
Published: Oct 17, 2009
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