Acenocoumarol Reactions 1664, p15 - 12 Aug 2017 Various toxicities: case report An 81-year-old woman developed hypotension, paleness and spontaneous haematoma with complete mammary necrosis and fatal multiple organ failure due to acenocoumarol [durations of treatment to reaction onsets not stated; not all outcomes stated]. The woman, who had a history of paroxysmal atrial fibrillation, started receiving acenocoumarol [route and dosage not stated]. She presented with hypotension, paleness and a spontaneous haematoma on the right breast. An analysis revealed haemoglobin of 7.9 mg/dL, leukocytes 14,200 and INR 12.58. An examination showed infected, suppurative and foul smelling necrosis in the right breast. The woman was subjected to debridement of necrotic tissue. She underwent aggressive medical surgical management, however, developed multiple organ failure with fatal outcome. Author comment: Complete mammary necrosis due to Perez-Guarinos CV, et al. Complete mammary necrosis due to acenocoumarol. Cirugia Espanola 93: 472, No. 7, Aug-Sep 2015. Available from: URL: http:// [Spanish; summarised from a translation] - Spain 803262573 0114-9954/17/1664-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 12 Aug 2017 No. 1664 Reactions Weekly Springer Journals


Reactions Weekly , Volume 1664 (1) – Aug 12, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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