Accumulation of CD11b + Gr-1 + cells in the lung, blood and bone marrow of mice infected with highly pathogenic H5N1 and H1N1 influenza viruses

Accumulation of CD11b + Gr-1 + cells in the lung, blood and bone marrow of mice infected with... Infection with pathogenic influenza viruses is associated with intense inflammatory disease. Here, we investigated the innate immune response in mice infected with H5N1 A/Vietnam/1203/04 and with reassortant human H1N1 A/Texas/36/91 viruses containing the virulence genes hemagglutinin (HA), neuraminidase (NA) and NS1 of the 1918 pandemic virus. Inclusion of the 1918 HA and NA glycoproteins rendered a seasonal H1N1 virus capable of inducing an exacerbated host innate immune response similar to that observed for highly pathogenic A/Vietnam/1203/04 virus. Infection with 1918 HA/NA:Tx/91 and A/Vietnam/1203/04 were associated with severe lung pathology, increased cytokine and chemokine production, and significant immune cell changes, including the presence of CD11b + Gr-1 + cells in the blood, lung and bone marrow. Significant differential gene expression in the lung included pathways for cell death, apoptosis, production and response to reactive oxygen radicals, as well as arginine and proline metabolism and chemokines associated with monocyte and neutrophil/granulocyte accumulation and/or activation. Arginase was produced in the lung of animals infected with A/Vietnam/1204. These results demonstrate that the innate immune cell response results in the accumulation of CD11b + Gr-1 + cells and products that have previously been shown to contribute to T cell suppression. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Accumulation of CD11b + Gr-1 + cells in the lung, blood and bone marrow of mice infected with highly pathogenic H5N1 and H1N1 influenza viruses

Loading next page...
 
/lp/springer_journal/accumulation-of-cd11b-gr-1-cells-in-the-lung-blood-and-bone-marrow-of-Yc0NUaWBJ3
Publisher
Springer Vienna
Copyright
Copyright © 2013 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-012-1593-3
Publisher site
See Article on Publisher Site

Abstract

Infection with pathogenic influenza viruses is associated with intense inflammatory disease. Here, we investigated the innate immune response in mice infected with H5N1 A/Vietnam/1203/04 and with reassortant human H1N1 A/Texas/36/91 viruses containing the virulence genes hemagglutinin (HA), neuraminidase (NA) and NS1 of the 1918 pandemic virus. Inclusion of the 1918 HA and NA glycoproteins rendered a seasonal H1N1 virus capable of inducing an exacerbated host innate immune response similar to that observed for highly pathogenic A/Vietnam/1203/04 virus. Infection with 1918 HA/NA:Tx/91 and A/Vietnam/1203/04 were associated with severe lung pathology, increased cytokine and chemokine production, and significant immune cell changes, including the presence of CD11b + Gr-1 + cells in the blood, lung and bone marrow. Significant differential gene expression in the lung included pathways for cell death, apoptosis, production and response to reactive oxygen radicals, as well as arginine and proline metabolism and chemokines associated with monocyte and neutrophil/granulocyte accumulation and/or activation. Arginase was produced in the lung of animals infected with A/Vietnam/1204. These results demonstrate that the innate immune cell response results in the accumulation of CD11b + Gr-1 + cells and products that have previously been shown to contribute to T cell suppression.

Journal

Archives of VirologySpringer Journals

Published: Jun 1, 2013

References

  • Subsets, expansion and activation of myeloid-derived suppressor cells
    Ribechini, E; Greifenberg, V; Sandwick, S; Lutz, MB
  • MyD88-dependent expansion of an immature Gr-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis
    Delano, MJ; Scumpia, PO; Weinstein, JS; Coco, D; Nagaraj, S; Kelly-Scumpia, KM; O’Malley, KA; Wynn, JL; Antonenko, S; Al-Quran, SZ; Swan, R; Chung, CS; Atkinson, MA; Ramphal, R; Gabrilovich, DI; Reeves, WH; Ayala, A; Phillips, J; Laface, D; Heyworth, PG; Clare-Salzler, M; Moldawer, LL
  • Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers
    Bronte, V; Kasic, T; Gri, G; Gallana, K; Borsellino, G; Marigo, I; Battistini, L; Iafrate, M; Prayer-Galetti, T; Pagano, F; Viola, A
  • Arginine in asthma and lung inflammation
    King, NE; Rothenberg, ME; Zimmermann, N

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off