Access to antimycobacterial and anticancer potential of some fused quinazolines

Access to antimycobacterial and anticancer potential of some fused quinazolines Two series of some various N-phenyl/benzothiazolyl acetamide-fused quinazoline derivatives were synthesized and tested for their antimycobacterial activity against M. tuberculosis H37Rv. Moreover, the synthesized analogs were also screened against human PC3 cells in order to explore their anticancer activity. The in vitro antimycobacterial screening revealed that, among the synthesized analogs, N-benzothiazolyl acetamide derivatives showed remarkable antimycobacterial activity. However, the best anticancer results were observed amongst the N-phenyl acetamide-substituted quinazoline derivatives. The newly synthesized compounds were characterized through IR, 1H NMR, 13C NMR, MS, and elemental analysis. Research on Chemical Intermediates Springer Journals

Access to antimycobacterial and anticancer potential of some fused quinazolines

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Springer Netherlands
Copyright © 2014 by Springer Science+Business Media Dordrecht
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
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