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Accelerated whole brain intracranial vessel wall imaging using black blood fast spin echo with compressed sensing (CS-SPACE)

Accelerated whole brain intracranial vessel wall imaging using black blood fast spin echo with... Objective Develop and optimize an accelerated, high-resolution (0.5 mm isotropic) 3D black blood MRI technique to reduce scan time for whole-brain intracranial vessel wall imaging. Materials and methods A 3D accelerated T -weighted fast-spin-echo prototype sequence using compressed sensing (CS- SPACE) was developed at 3T. Both the acquisition [echo train length (ETL), under-sampling factor] and reconstruction parameters (regularization parameter, number of iterations) were first optimized in 5 healthy volunteers. Ten patients with a variety of intracranial vascular disease presentations (aneurysm, atherosclerosis, dissection, vasculitis) were imaged with SPACE and optimized CS-SPACE, pre and post Gd contrast. Lumen/wall area, wall-to-lumen contrast ratio (CR), enhance- ment ratio (ER), sharpness, and qualitative scores (1–4) by two radiologists were recorded. Results The optimized CS-SPACE protocol has ETL 60, 20% k-space under-sampling, 0.002 regularization factor with 20 iterations. In patient studies, CS-SPACE and conventional SPACE had comparable image scores both pre- (3.35 ± 0.85 vs. 3.54 ± 0.65, p = 0.13) and post-contrast (3.72 ± 0.58 vs. 3.53 ± 0.57, p = 0.15), but the CS-SPACE acquisition was 37% faster (6:48 vs. 10:50). CS-SPACE agreed with SPACE for lumen/wall area, ER measurements and sharpness, but margin- ally reduced the CR. Conclusion In the evaluation of intracranial vascular disease, CS-SPACE provides a substantial reduction in scan time compared to http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Magnetic Resonance Materials in Physics, Biology and Medicine Springer Journals

Accelerated whole brain intracranial vessel wall imaging using black blood fast spin echo with compressed sensing (CS-SPACE)

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Publisher
Springer Journals
Copyright
Copyright © 2017 by ESMRMB
Subject
Medicine & Public Health; Imaging / Radiology; Computer Appl. in Life Sciences; Solid State Physics; Biomedical Engineering; Health Informatics
ISSN
0968-5243
eISSN
1352-8661
DOI
10.1007/s10334-017-0667-3
Publisher site
See Article on Publisher Site

Abstract

Objective Develop and optimize an accelerated, high-resolution (0.5 mm isotropic) 3D black blood MRI technique to reduce scan time for whole-brain intracranial vessel wall imaging. Materials and methods A 3D accelerated T -weighted fast-spin-echo prototype sequence using compressed sensing (CS- SPACE) was developed at 3T. Both the acquisition [echo train length (ETL), under-sampling factor] and reconstruction parameters (regularization parameter, number of iterations) were first optimized in 5 healthy volunteers. Ten patients with a variety of intracranial vascular disease presentations (aneurysm, atherosclerosis, dissection, vasculitis) were imaged with SPACE and optimized CS-SPACE, pre and post Gd contrast. Lumen/wall area, wall-to-lumen contrast ratio (CR), enhance- ment ratio (ER), sharpness, and qualitative scores (1–4) by two radiologists were recorded. Results The optimized CS-SPACE protocol has ETL 60, 20% k-space under-sampling, 0.002 regularization factor with 20 iterations. In patient studies, CS-SPACE and conventional SPACE had comparable image scores both pre- (3.35 ± 0.85 vs. 3.54 ± 0.65, p = 0.13) and post-contrast (3.72 ± 0.58 vs. 3.53 ± 0.57, p = 0.15), but the CS-SPACE acquisition was 37% faster (6:48 vs. 10:50). CS-SPACE agreed with SPACE for lumen/wall area, ER measurements and sharpness, but margin- ally reduced the CR. Conclusion In the evaluation of intracranial vascular disease, CS-SPACE provides a substantial reduction in scan time compared to

Journal

Magnetic Resonance Materials in Physics, Biology and MedicineSpringer Journals

Published: Dec 5, 2017

References