Featured Poster Session 1 FP 1-2 Repeated remote ischemic conditioning preserves FP 1-1 systolic left ventricle function and increases NRG-1 expression following myocardial infarction Novel regulators of cardiomyocyte proliferation in rats and regeneration in mouse and human P. M. Pilz, M. Lang, O. Hamza, I. Fonseca- Gonçalves, T. Schuetz, T. Dolejsi, M. Adamowicz-Brice, M. Inci, B. Podesser, A. Kiss C. C. Morgan, T. J. Aitman, J. M. Penninger, B. J. Haubner Center for Biomedical Research, Ludwig Boltzmann Cluster for Cardiovascular Research Department of Internal Medicine III, Cardiology, Innsbruck Medical University Vienna, Vienna, Austria Medical University, Innsbruck, Austria Centre for Genomic and Experimental Medicine, University of Background: Adverse left ventricle (LV) remodelling fol- Edinburgh, Edinburgh, United Kingdom lowing myocardial infarction (MI) plays a key role in the pro- Imperial College, National Heart and Lung Institute, Faculty gression of congestive heart failure (HF). Recombinant human of Medicine, London, United Kingdom Neuregulin-1 (rhNRG-1) has been demonstrated to have both Institute of Molecular Biotechnology of the Austrian Academy anti-fibrotic and anti-inflammatory effects. Chronic admin- of Sciences, Vienna, Austria istration of rhNRG-1 markedly improved LV ejection fraction (LVEF) and coronary microcirculation in patients with HF. Background: The adult m ammalian heart has little regen-
Wiener klinische Wochenschrift – Springer Journals
Published: May 28, 2018
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