J. of Cardiovasc. Trans. Res. (2018) 11:58–70 https://doi.org/10.1007/s12265-017-9770-0 Published online: 16 January 2018 The Author(s) 2018. This article is an open access publication reperfusion (PR), first reducing myocardial oxygen demand by activating Overview and Mission of the 2017 A-CURE an acute mechanical circulatory support device while delaying coronary Symposium reperfusion primary unloading (PU) reduces myocardial damage in models of acute myocardial infarction (AMI). The 2nd Annual Acute Cardiac Unloading and Recovery (A-CURE) Hypothesis: The purpose of this study was to explore the long-term Symposium was held in Barcelona, Spain, on August 25, 2017. Over 100 outcomes associated with primary unloading before myocardial reperfu- clinical and basic researchers from around the world participated in this sion compared to primary reperfusion alone. year’s conference, which was hosted by the A-CURE Working Group. Methods: Animals were randomized into two groups, the control arm (PR) The mission of the A-CURE Working Group is to advance the science and the intervention arm (PU). The PR cohort underwent 90 min of left and mechanistic understanding of acute cardiac unloading and to support anterior descending (LAD) occlusion followed by 120 min of reperfusion. the translation of basic and clinical research into therapies aimed at heart The
Journal of Cardiovascular Translational Research – Springer Journals
Published: Jan 16, 2018
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