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Russian Journal of Developmental Biology, Vol. 36, No. 5, 2005, pp. 308–334. Translated from Ontogenez, Vol. 36, No. 5, 2005, pp. 368–400. Original Russian Text Copyright © 2005. Abstracts of Posters Presented at The Scientific School “Current Problems of Developmental Biology and Biotechnology” Genetic Variability and Functioning of Genome in Ontogenesis S. A. Aleksandrova Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia E-mail: svetal@mail.cytspb.rssi.ru The concept of absolute stability of the cell genome Genetic variability of random bred mice exceeded sev- has been increasingly criticized during the last decades. eral fold that in the linear mice. The highest DNA vari- For example, it was shown that in the normal genome, ability was recorded in the testes, small intestine, liver, point mutations occurred with a high frequency and heart, and lungs, and the lowest, in the brain, placenta, variability of mink- and microsatellites was described. and spleen. It was shown that genetic variability in the Transposons and homologous translocations also con- genome of mouse organs and tissues did not prevent tribute to the genetic variability. For quantitative assess- their normal functioning. At the same time, high vari- ment of all these types of mutations, RAPD-PCR for ability in
Russian Journal of Developmental Biology – Springer Journals
Published: Oct 18, 2005
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