Abstracts of papers and posters at the International Symposium on the Inactivation of X Chromosomes in Mammals Novosibirsk, September 6–12, 1999 PAPERS

Abstracts of papers and posters at the International Symposium on the Inactivation of X... Russian Journal of Developmental Biology; Vol. 31, No. 4, 2000, pp. 233-269. From Ontogenez, Vol. 31, No. 4, 2000, pp. 284-320. Original English Text Copyright 9 2000. Abstracts of Papers and Posters at the International Symposium on the Inactivation of X Chromosomes in Mammals ~ Novosibirsk, September 6-12, 1999 PAPERS The Effects of Xist Transgenes on the Mouse Y Chromosome M. L. Ager*, S. Duthie**, S. Morse*, N. Brockdorff**, and S. D. M. Brown* * MRC Mammalian Genetics Unit and UK Mouse Genome Center, Harwell, UK ** X-Inactivation Group, MRC Clinical Sciences Center, London, UK Much of the transgenic work involving the Xist gene function in every cell, as we only see approximately has been carried out in ES cells. We have constructed a 50% of cells with stable Xist expression. After inactiva- mouse line containing four copies of a 240 kb XistYAC tion has occurred (8.5 dpc), we no longer see Xist expres- inserted near the distal end of the mouse Y chromo- sion from the X chromosome and see stable Xist expres- some. Here, we demonstrate that the Xist transgenes sion from the Y chromosome in about 20% of cells. can function as a counting center in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Developmental Biology Springer Journals

Abstracts of papers and posters at the International Symposium on the Inactivation of X Chromosomes in Mammals Novosibirsk, September 6–12, 1999 PAPERS

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Publisher
Nauka/Interperiodica
Copyright
Copyright © 2000 by MAIK “Nauka/Interperiodica”
Subject
Life Sciences; Developmental Biology; Animal Anatomy / Morphology / Histology
ISSN
1062-3604
eISSN
1608-3326
D.O.I.
10.1007/BF02758832
Publisher site
See Article on Publisher Site

Abstract

Russian Journal of Developmental Biology; Vol. 31, No. 4, 2000, pp. 233-269. From Ontogenez, Vol. 31, No. 4, 2000, pp. 284-320. Original English Text Copyright 9 2000. Abstracts of Papers and Posters at the International Symposium on the Inactivation of X Chromosomes in Mammals ~ Novosibirsk, September 6-12, 1999 PAPERS The Effects of Xist Transgenes on the Mouse Y Chromosome M. L. Ager*, S. Duthie**, S. Morse*, N. Brockdorff**, and S. D. M. Brown* * MRC Mammalian Genetics Unit and UK Mouse Genome Center, Harwell, UK ** X-Inactivation Group, MRC Clinical Sciences Center, London, UK Much of the transgenic work involving the Xist gene function in every cell, as we only see approximately has been carried out in ES cells. We have constructed a 50% of cells with stable Xist expression. After inactiva- mouse line containing four copies of a 240 kb XistYAC tion has occurred (8.5 dpc), we no longer see Xist expres- inserted near the distal end of the mouse Y chromo- sion from the X chromosome and see stable Xist expres- some. Here, we demonstrate that the Xist transgenes sion from the Y chromosome in about 20% of cells. can function as a counting center in

Journal

Russian Journal of Developmental BiologySpringer Journals

Published: Nov 18, 2007

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