Russian Journal of Developmental Biology; Vol. 31, No. 4, 2000, pp. 233-269. From Ontogenez, Vol. 31, No. 4, 2000, pp. 284-320. Original English Text Copyright 9 2000. Abstracts of Papers and Posters at the International Symposium on the Inactivation of X Chromosomes in Mammals ~ Novosibirsk, September 6-12, 1999 PAPERS The Effects of Xist Transgenes on the Mouse Y Chromosome M. L. Ager*, S. Duthie**, S. Morse*, N. Brockdorff**, and S. D. M. Brown* * MRC Mammalian Genetics Unit and UK Mouse Genome Center, Harwell, UK ** X-Inactivation Group, MRC Clinical Sciences Center, London, UK Much of the transgenic work involving the Xist gene function in every cell, as we only see approximately has been carried out in ES cells. We have constructed a 50% of cells with stable Xist expression. After inactiva- mouse line containing four copies of a 240 kb XistYAC tion has occurred (8.5 dpc), we no longer see Xist expres- inserted near the distal end of the mouse Y chromo- sion from the X chromosome and see stable Xist expres- some. Here, we demonstrate that the Xist transgenes sion from the Y chromosome in about 20% of cells. can function as a counting center in
Russian Journal of Developmental Biology – Springer Journals
Published: Nov 18, 2007
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