Absence of infection in pigs inoculated with high-titre recombinant PERV-A/C

Absence of infection in pigs inoculated with high-titre recombinant PERV-A/C Porcine endogenous retroviruses (PERVs) represent a risk for xenotransplantation using pig cells or organs since they are integrated in the genome of all pigs and infect human cells in vitro . Recombinants between PERV-A and PERV-C have been described in pigs in vivo and found de novo integrated in the genome of somatic cells, but not in the germ line. To study whether PERV-A/C can infect and have a pathogenic effect in normal pigs, German landrace pigs were inoculated with high-titre PERV-A/C. No provirus integration was found in blood cells or in various tissues, and no antibody production was observed, indicating the absence of infection. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Absence of infection in pigs inoculated with high-titre recombinant PERV-A/C

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Springer Vienna
Copyright © 2011 by Springer-Verlag
Biomedicine; Infectious Diseases; Medical Microbiology ; Virology
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