ABO genotype-phenotype discrepancy due to chimerism resolved by clonal separation

ABO genotype-phenotype discrepancy due to chimerism resolved by clonal separation Ann Hematol (2017) 96:1583–1585 DOI 10.1007/s00277-017-3048-0 LETTER TO THE EDITOR ABO genotype-phenotype discrepancy due to chimerism resolved by clonal separation 1 2 1 3 Hyung-Seok Yang & Jae Gyun Shin & John Jeongseok Yang & Jae-Cheol Choi & 1 2 2 2 2 Tae Sung Park & Ja Young Lee & Hye Ran Kim & Jeong Nyeo Lee & Seung Hwan Oh Received: 20 March 2017 /Accepted: 6 June 2017 /Published online: 20 June 2017 Springer-Verlag GmbH Germany 2017 Dear editor, populations in a gel column with anti-A antibodies, while Blood group chimerism is a rare phenomenon occurring as serum typing identified anti-B antibodies (Fig. 1a). Her either congenital or acquired. Because two genetically distinct RBCs agglutinated very weakly (±) with anti-A1 reagents cell lines derived from two or more zygotes in one body are and strongly (3+) with anti-H reagents by manual tube tech- present, chimerism differs from mosaicism which refers to the nique. The patient’s samples were sent to the regional refer- presence of different cell lines all arising from a single zygote ence laboratory for ABO genotyping. Her genotype was re- [1]. Since it is usually recognized at the time of blood group ported as O/O http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Hematology Springer Journals

ABO genotype-phenotype discrepancy due to chimerism resolved by clonal separation

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag GmbH Germany
Subject
Medicine & Public Health; Hematology; Oncology
ISSN
0939-5555
eISSN
1432-0584
D.O.I.
10.1007/s00277-017-3048-0
Publisher site
See Article on Publisher Site

Abstract

Ann Hematol (2017) 96:1583–1585 DOI 10.1007/s00277-017-3048-0 LETTER TO THE EDITOR ABO genotype-phenotype discrepancy due to chimerism resolved by clonal separation 1 2 1 3 Hyung-Seok Yang & Jae Gyun Shin & John Jeongseok Yang & Jae-Cheol Choi & 1 2 2 2 2 Tae Sung Park & Ja Young Lee & Hye Ran Kim & Jeong Nyeo Lee & Seung Hwan Oh Received: 20 March 2017 /Accepted: 6 June 2017 /Published online: 20 June 2017 Springer-Verlag GmbH Germany 2017 Dear editor, populations in a gel column with anti-A antibodies, while Blood group chimerism is a rare phenomenon occurring as serum typing identified anti-B antibodies (Fig. 1a). Her either congenital or acquired. Because two genetically distinct RBCs agglutinated very weakly (±) with anti-A1 reagents cell lines derived from two or more zygotes in one body are and strongly (3+) with anti-H reagents by manual tube tech- present, chimerism differs from mosaicism which refers to the nique. The patient’s samples were sent to the regional refer- presence of different cell lines all arising from a single zygote ence laboratory for ABO genotyping. Her genotype was re- [1]. Since it is usually recognized at the time of blood group ported as O/O

Journal

Annals of HematologySpringer Journals

Published: Jun 20, 2017

References

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